基本信息
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I am an excited protein scientist who wishes to understand how diverse chemical reactions are catalysed by macromolecular catalysts (enzymes) evolved in living creatures. To this end, I combine molecular biology, biochemistry, and structural biology (X-ray crystallography and cryo-electron microscopy) to obtain atomic-level molecular insights into the three-dimensional structure, function, and regulation of enzymes. I also develop protein engineering strategies and chemical tools that selectively modulate molecular functions of enzymes; exploitable in basic research as well as in environmentally friendly cutting-edge biotechnologies. The long-term goal of my research is to address an unanswered fundamental question: how do enzymes acquire the structural diversity and conformational flexibility that allow them to evolve towards new molecular function?
Research Interests
Papers共 80 篇Author StatisticsCo-AuthorSimilar Experts
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Vojtech Cima,Antonin Kunka,Ekaterina Grakova,Joan Planas-Iglesias, Martin Havlasek, Madhumalar Subramanian,Michal Beloch,Martin Marek,Katerina Slaninova,Jiri Damborsky,Zbynek Prokop,David Bednar,
biorxiv(2024)
crossref(2024)
Methods in molecular biology (Clifton, N.J.) (2023): 293-318
bioRxiv (Cold Spring Harbor Laboratory)no. 1 (2023): 38-25
CHEMCATCHEMno. 19 (2023)
Acta crystallographica. Section D, Structural biologyno. 11 (2023): 956-970
Michal Nemergut,Daniel Pluskal, Jana Horackova,Tereza Sustrova,Jan Tulis,Tomas Barta,Racha Baatallah,Glwadys Gagnot,Veronika Novakova,Marika Majerova, Karolina Sedlackova,Sérgio M. Marques,
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