The aim of my research is to understand the molecular mechanisms that govern how cells maintain the quality of proteins during cellular stress, towards developing novel strategies for therapeutic intervention in cancer and neurodegenerative diseases.

Of particular interest, we seek to gain structural and mechanistic insights into how the Unfolded Protein Response, a key cell signaling system that maintains protein homeostasis within the ER, is activated and how the signal is subsequently propagated.

We utilize a multidisciplinary approach that encompasses structural biology, biochemistry, and cellular techniques, to characterize proteins and complexes involved in ER stress pathways.