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Bio
Professor
Facultad de Ciencias
Universidad de Chile
Director
Millennium Institute Center for Genome Regulation
Miguel Allende received his Bachelor’s in Biology from the Catholic University of Chile in 1987 and a PhD from the University of Pennsylvania in 1994. At the beginning of his doctoral studies with Dr. Eric Weinberg, he had the opportunity to carry out research stays in the labs of Monte Westerfield and Christianne Nüsslein-Volhard, where he became a convert to the zebrafish as a model. His thesis involved the analysis of transcription factors important for neural and muscle specification, publishing several pioneering papers. At the time, several labs were developing genetic tools in zebrafish and Dr. Allende then joined the lab of Dr. Nancy Hopkins at MIT who was trying to develop insertional as an alternative to chemical mutagenesis. During his postdoc, and together with a dedicated team of co-workers, they were able to use modified retroviruses to efficiently mutagenize genes and to rapidly identify the lesioned loci by reverse PCR cloning. In 1998, Dr. Allende returned to his home country of Chile, where he established the first zebrafish lab in Latin America and started his independent career at the Faculty of Science, University of Chile. Since then, he has worked on several topics including neural development, neuronal regeneration, innate immunity, metal toxicology, infection models and genomics. His lab has developed several techniques such as a testing method for enhancer activity, a quantitative inflammation assay, electroablation and the generation of chimeras through xenotransplants, using cells of diverse origins, from algae to mammallian pluripotent stem cells. He has published over 100 papers all but a few of which involve zebrafish research. Currently, he leads the Center for Genome Regulation, and also the Chilean 1000 Genomes Initiative, which aims to sequence and analyze the genomes of Chilean endemic species and of the Chilean human population.
Dr Allende was incorporated into the Chilean Academy of Sciences in 2015, among other distinctions. He was President of the University’s Board for Institutional Evaluation (2020-2021) and was chair of the Biology study section of FONDECYT, the Chilean science funding agency. He was President of the Chilean Society for Cell Biology and Treasurer of the Latin American Society for Developmental Biology. He was a founding member and served on the first Board of the Latin American Zebrafish Network (LAZEN) and also of the International Zebrafish Society (IZFS). In addition to his research, Dr. Allende is interested in promoting science education by using the zebrafish as an educational tool. He participates in the country’s Portable Labs Program that trains teachers to use materials provided by participating research labs to have children perform experiments in the classroom. The program has expanded to reach dozens of schools in all of the regions of the country and educators from all over Latin America have come to be trained in its implementation.
Research Interests
Papers共 148 篇Author StatisticsCo-AuthorSimilar Experts
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N. G. Papa, J. Sotelo-Silveira, L. Inchausti, C. Valdivieso, L. Pereiro, F. Gajardo, A. Di Genova, A. Glavic,C. Chalar,N. Berois,Miguel L. Allende,Maria Jose Arezo
Environmental Biology of Fishespp.1-25, (2024)
Felipe Gajardo, Luisa Pereiro,Maria Jose Arezo,Gino Nardocci, Natalia Rojas,Veronica Gutiérrez,Nicolas Papa,Nibia Berois,Ariel Orellana,Rodrigo A Gutierrez,Mauricio González,Marco Mendez,
crossref(2024)
SCIENCE ADVANCESno. 3 (2024): eadj5991-eadj5991
BMC genomicsno. 1 (2024): 614-614
International journal of molecular sciencesno. 8 (2023): 7485-7485
Sanae Kobayashi,Jonathan E. Maldonado,Alexis Gaete, Ingrid Araya,Constanza Aguado-Norese,Nicolás Cumplido,Sebastián Díaz,Alonso Espinoza, Edelmira Fernández,Felipe Gajardo, Felipe González-Ordenes, Khantati Hauyon,
Karen Fehrmann-Cartes,Matías Vega, Frank Vera,Ricardo Enríquez,Carmen G. Feijóo,Miguel L. Allende,Adrián J. Hernández,Alex Romero
Frontiers in Animal Science (2022)
crossref(2022)
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