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The Kronenberg lab focuses on understanding innate-like lymphocytes, mainly natural killer T (NKT) cells, a subset of T cells that recognizes glycolipids and is involved in a variety of immune responses including autoimmune, anti-tumoral responses and antimicrobial responses. Kronenberg also has research in mucosal immunology and on the development of inflammatory bowel diseases.
Kronenberg's work had a major impact in defining how glycolipid antigens are taken into cells and processed in lysosomes and unraveled the intracellular traffic of CD1d, which is the MHC class I molecule that presents lipid antigens. He has led the field in defining microbial antigens from environmental bacteriaand from pathogenic microbes for mouse and human NKT cells,characterizing the biochemistry of antigen recognition, and has shown that NKT cells are protective in Lyme disease and pneumonia. In the mucosal immune system, major findings from the Kronenberg laboratory have identified functions of another MHC class I antigen presenting molecule expressed in intestine epithelium, the Thymus Leukemia antigen. His work has determined how the balance of regulatory versus pro-inflammatory responses occurs, with breakthroughs in understanding the roles of retinoic acid and IL-10. Recently, they demonstrated that HVEM, a TNF receptor homolog, has enormous influence on the mucosal immune response by triggering protective innate anti-microbial responses against important pathogens by innate lymphoid cells type 3 (ILC3) and epithelial cells in the intestine.
Kronenberg's work had a major impact in defining how glycolipid antigens are taken into cells and processed in lysosomes and unraveled the intracellular traffic of CD1d, which is the MHC class I molecule that presents lipid antigens. He has led the field in defining microbial antigens from environmental bacteriaand from pathogenic microbes for mouse and human NKT cells,characterizing the biochemistry of antigen recognition, and has shown that NKT cells are protective in Lyme disease and pneumonia. In the mucosal immune system, major findings from the Kronenberg laboratory have identified functions of another MHC class I antigen presenting molecule expressed in intestine epithelium, the Thymus Leukemia antigen. His work has determined how the balance of regulatory versus pro-inflammatory responses occurs, with breakthroughs in understanding the roles of retinoic acid and IL-10. Recently, they demonstrated that HVEM, a TNF receptor homolog, has enormous influence on the mucosal immune response by triggering protective innate anti-microbial responses against important pathogens by innate lymphoid cells type 3 (ILC3) and epithelial cells in the intestine.
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