基本信息
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Career Trajectory
Bio
I have more than 30 years experience in the computer-aided design of novel medicines, particularly in the areas of infectious diseases and neuroscience. This includes contributions to the invention of ligands for over 60 different therapeutic targets. Successful design examples include one of the first marketed HIV protease inhibitors, Crixivan, as well as a second generation Hepatitis C protease inhibitor, grazoprevir, which was combined with the HCV NS5A inhibitor elbasvir in Zepatier.
With over 100 scientific publications and issued patents and, as a former chair of both the American Chemical Society Computers in Chemistry division and the Gordon Research Conference on Computer-Aided Drug Design, I am also actively involved in the structure-based design community.
With over 100 scientific publications and issued patents and, as a former chair of both the American Chemical Society Computers in Chemistry division and the Gordon Research Conference on Computer-Aided Drug Design, I am also actively involved in the structure-based design community.
Research Interests
Papers共 131 篇Author StatisticsCo-AuthorSimilar Experts
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David Harrison, Andy Billinton,Mark G. Bock,John R. Doedens,Christopher A. Gabel,M. Katharine Holloway,Roderick A. Porter, Valerie Reader,Jane Scanlon, Kenneth Schooley,Alan P. Watt
Journal of medicinal chemistryno. 21 (2023): 14897-14911
Veerabahu Shanmugasundaram,Jürgen Bajorath,Ralph E. Christoffersen,James D. Petke, W. Jeffrey Howe, Mark A. Johnson,Dimitris K. Agrafiotis,Pil Lee,Leslie A. Kuhn,Jay T. Goodwin,M. Katharine Holloway, Thompson N. Doman,
David Harrison, Mark G Bock,John R Doedens,Christopher A Gabel,M Katharine Holloway,Arwel Lewis,Jane Scanlon, Andrew Sharpe, Iain D Simpson,Pamela Smolak,Grant Wishart,Alan P Watt
Wensheng Yu,Jian Liu,Dane Clausen,Younong Yu,Joseph L Duffy,Ming Wang, Shouning Xu, Lin Deng,Suzuki Takao,Christine C Chung,Robert W Myers,Daniel J Klein,
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