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My research group performs pharmacogenetic research, from gene-finding to clinical implementation, aiming to optimise treatment for the individual patient. I started my group on pharmacogenetics focussing on gene-finding in rheumatoid arthritis, for which I set up a productive international collaboration. I led the first genome-wide association analysis for anti-TNF treatment outcome and the first large-scale genetic study showing how proxy measures for standard clinical outcomes can successfully be applied. Lately I focus the gene-finding research on pharmacogenetic studies in pediatrics and pain. Together with Dr. Maroeska te Loo, I set up the Genetics of Osteosarcoma (GO)-consortium, which includes thirteen (inter)national groups enabling us to assemble the world-wide largest cohort of children treated with platinum agents (including osteosarcoma and brain tumors). For the genetic studies in pain a study is ongoing that follows patients that undergo an operation for the development of acute and/or chronic. This cohort will be used for genetic studies to unravel the background of pain but also the pharmacogenetics of pain.
In addition to my gene-finding work, I have pushed the uptake of pharmacogenetics into clinical care. For this, I led the world-wide largest randomized controlled trial for cost-effectiveness of thiopurine-S-methyltransferase genotyping prior to thiopurine treatment in IBD. I am currently involved in similar multicentre studies. One in psychiatry investigating cost-effectiveness of pharmacogenetic testing prior to tricyclic anti-depressants treatment and a study investigating cost-effectiveness of pharmacogenetic testing prior to clopidogrel treatment in peripheral artrial disease.
Research Interests
Papers共 212 篇Author StatisticsCo-AuthorSimilar Experts
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Sophie E. ter Hark,Marieke J. H. Coenen,Cornelis F. Vos,Rob E. Aarnoutse,Willem A. Nolen, Tom K. Birkenhager, Walter W. van den Broek,Arnt F. A. Schellekens, Robbert-Jan Verkes,Joost G. E. Janzing
Painno. 9 (2023): 1891-1911
The application of clinical genetics (2023): 131-137
Stefan A. J. Buck, Marinda Meertens, Frederiek M. F. van Ooijen,Esther Oomen-de Hoop, Evert de Jonge,Marieke J. H. Coenen,Andries M. Bergman,Stijn L. W. Koolen,Ronald de Wit,Alwin D. R. Huitema,Ron H. N. van Schaik,Ron H. J. Mathijssen
BIOMEDICINE & PHARMACOTHERAPY (2023): 115890-115890
Frontiers in pharmacology (2023): 1159307
Pharmacogenomicsno. 11 (2023): 629-639
Cornelis F. Vos,Sophie E. ter Hark,Arnt F. A. Schellekens,Jan Spijker, Annemarie van der Meij, Anne J. Grotenhuis,Raluca Mihaescu,Wietske Kievit,Rogier Donders,Rob E. Aarnoutse,Marieke J. H. Coenen,Joost G. E. Janzing
JAMA network openno. 5 (2023)
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