基本信息
views: 76
Career Trajectory
Bio
My long term career objective has been to provide molecular targets, develop tools and characterize models to encourage greater pharmaceutical investment in disease-modifying therapeutics aimed at neuroprotection (‘precision medicine’). I have long had an interest in dementia, from my PhD dissertation was on ‘The genetics of age-associated cognitive dysfunction in Down syndrome’, including the role of APOE, to linkage analysis implicating increased alpha-synuclein gene dosage as the cause of Lewy body parkinsonism-dementia, to comparative high-throughput sequencing in families and populations to identify the genetic contribution to neurodegenerative trait components. I have used genetic insights to better understand genotype-phenotype correlations in man and in mouse models, with cre-loxP methods and brain slice biochemistry and physiology. In recent years I built and directed the Centre for Applied Neurogenetics and Translational Neuroscience at the University of British Columbia, and founded Neurocode Labs Inc., the only company in Canada that is clinically-accredited in medical genetics to return results from whole exome sequencing, primarily in the context of pediatric seizure disorders. As part of both endeavors, integrating genetic information, bioinformatics and web-development, my team created NeuroSeq (www.neuroseq.ca), a genome browser to enable sharing and global collaboration between neurologists and academic researchers. This proposal is a community-based effort focused on brain health and neuroprotection that aims to understand what it will take to deliver genetic information to the public. We aim to lower the risk of cognitive decline and dementia, in an underserved and socioeconomically disadvantaged sample from the population of Florida, in a meaningful and ethically-responsible fashion. It is a pilot application to improve population health, methodologically simplistic but nonetheless challenging in that it aims to modify individual behavior to lower the overall risk and incidence of Alzheimer’s disease.
Research Interests
Papers共 630 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
A. Gopinath,A. Ramirez-Zamora, S. Franks,T. Riaz,A. Smith, G. Dizon, L. Hornstein,J. Follett, C. Swartz, J. Bravo, E.L. Kugelmann,M. Farrer,
medrxiv(2024)
NPJ Parkinson's diseaseno. 1 (2024): 113-113
medRxiv : the preprint server for health sciences (2024)
bioRxiv : the preprint server for biology (2024)
Adithya Gopinath,Adolfo Ramirez-Zamora, Stephen Franks,Tabish Riaz,Aidan Smith, Glen Dizon, Lauryn Hornstein,Jordan Follett,Camille Swartz, Jonathan Bravo, E Lee Kugelmann,Matthew Farrer,
Journal of Parkinson's diseaseno. 4 (2024): 883-888
MOVEMENT DISORDERSno. 2 (2024): 249-258
Cloé Domenighetti,Pierre-Emmanuel Sugier,Ashwin Ashok Kumar Sreelatha,Claudia Schulte,Sandeep Grover,Berta Portugal,Pei-Chen Lee, Patrick May, Dheeraj Bobbili, Milena Radivojkov Blagojevic,Peter Lichtner,Andrew B Singleton,
Neurologyno. 3 (2024): e209620-e209620
Movement disorders : official journal of the Movement Disorder Societyno. 4 (2024): 751-753
Movement disorders : official journal of the Movement Disorder Societyno. 10 (2023): 1837-1849
medRxiv (Cold Spring Harbor Laboratory)no. 1 (2023): 1-8
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn