基本信息
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Career Trajectory
Bio
Research Interest
Our research addresses the mechanism and consequences of protein S-palmitoylation, a reversible posttranslational modification of proteins that regulates membrane association, protein trafficking, and protein stability. Discovered in 2002, the DHHC (Asp-His-His-Cys) protein S-acyltransferases are responsible for palmitoylation of proteins on the cytoplasmic leaflet of cell membranes. Our recent studies have revealed the catalytic mechanism of DHHC proteins and current work is focused on understanding how DHHC proteins are regulated by posttranslational modifications and oligomerization. We also have a longstanding interest in lipidation of cell signaling proteins and we have recently identified an alternative CaaX processing pathway for Cdc42 and Ral GTPases. Work is ongoing to elucidate how the alternatively processed isoforms bypass conventional CaaX processing and how they are functionally distinct from the conventionally processed isoforms. A third project is to determine the molecular mechanisms that underlie a syndromic form of X-linked intellectual disability caused by mutations in the ZDHHC9 gene. The objectives are to identify the substrates of DHHC9 by comparing the palmitoylomes of wild type and ZDHHC9 knockout mice and determine if ZDHHC9 knockout mice display altered behaviors in assays of cognitive, sensory, and motor functions.
Awards and Honors
2009, Academic Women’s Network Mentor Award
2009, Fellow, American Association for the Advancement of Science
2001-2004, Established Investigator, American Heart Association
2001, Special Recognition – Outstanding Faculty Mentor Awards
Our research addresses the mechanism and consequences of protein S-palmitoylation, a reversible posttranslational modification of proteins that regulates membrane association, protein trafficking, and protein stability. Discovered in 2002, the DHHC (Asp-His-His-Cys) protein S-acyltransferases are responsible for palmitoylation of proteins on the cytoplasmic leaflet of cell membranes. Our recent studies have revealed the catalytic mechanism of DHHC proteins and current work is focused on understanding how DHHC proteins are regulated by posttranslational modifications and oligomerization. We also have a longstanding interest in lipidation of cell signaling proteins and we have recently identified an alternative CaaX processing pathway for Cdc42 and Ral GTPases. Work is ongoing to elucidate how the alternatively processed isoforms bypass conventional CaaX processing and how they are functionally distinct from the conventionally processed isoforms. A third project is to determine the molecular mechanisms that underlie a syndromic form of X-linked intellectual disability caused by mutations in the ZDHHC9 gene. The objectives are to identify the substrates of DHHC9 by comparing the palmitoylomes of wild type and ZDHHC9 knockout mice and determine if ZDHHC9 knockout mice display altered behaviors in assays of cognitive, sensory, and motor functions.
Awards and Honors
2009, Academic Women’s Network Mentor Award
2009, Fellow, American Association for the Advancement of Science
2001-2004, Established Investigator, American Heart Association
2001, Special Recognition – Outstanding Faculty Mentor Awards
Research Interests
Papers共 136 篇Author StatisticsCo-AuthorSimilar Experts
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Nature Reviews Molecular Cell Biologyno. 6 (2024): 1-22
Tao Yu,Dan Hou, Jiaqi Zhao,Xuan Lu,Wendy K Greentree, Qian Zhao,Min Yang, Don-Gerard Conde,Maurine E Linder,Hening Lin
Severin Lechner,Martin Ian P. Malgapo,Christian Grätz,Raphael R. Steimbach, Agnes Baron,Patrick Rüther,Simon Nadal, Carmen Stumpf,Christina Loos,Xin Ku,Polina Prokofeva,Ludwig Lautenbacher,
crossref(2021)
Severin Lechner,Martin Malgapo,Christian Grätz, Agnes Baron,Patrick Leopold Rüther,Simon Nadal, Carmen Stumpf,Christina Loos,Xin Ku,Polina Prokofeva,Ludwig Lautenbacher,Tino Heimburg,
semanticscholar(2021)
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Author Statistics
#Papers: 138
#Citation: 13965
H-Index: 55
G-Index: 118
Sociability: 6
Diversity: 0
Activity: 0
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