基本信息
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Bio
Major Research Interests
Tissue stem cells are present in every adult tissue and generally exist in a dormant state. When a tissue undergoes stress or is in a critical state, the inherent stem cells are activated by an as yet-to-be-defined signal to re-enter the cell cycle for self-renewal and differentiation into cells that aid in reconstruction of that tissue. In this manner, tissue stem cells participate in maintenance of homeostasis at the cell- or tissue-level. In our research, we seek to clarify how the signals aroused from neighboring cells or from other tissues regulate the maintenance, proliferation and differentiation of tissue stem cells, and how the tissue stem cell network is related to the maintenance of vital tissue functions. Our ultimate goal is to develop stem cell biology from a new perspective. By identifying multi-potential stem cells contained in the bone marrow stromal cell population that can be experimentally manipulated to differentiate into cells that have the potential to trans-differentiate and contribute to the repair of other tissue types, we believe we are making unique contributions to stem cell biology and regenerative medicine.
Tissue stem cells are present in every adult tissue and generally exist in a dormant state. When a tissue undergoes stress or is in a critical state, the inherent stem cells are activated by an as yet-to-be-defined signal to re-enter the cell cycle for self-renewal and differentiation into cells that aid in reconstruction of that tissue. In this manner, tissue stem cells participate in maintenance of homeostasis at the cell- or tissue-level. In our research, we seek to clarify how the signals aroused from neighboring cells or from other tissues regulate the maintenance, proliferation and differentiation of tissue stem cells, and how the tissue stem cell network is related to the maintenance of vital tissue functions. Our ultimate goal is to develop stem cell biology from a new perspective. By identifying multi-potential stem cells contained in the bone marrow stromal cell population that can be experimentally manipulated to differentiate into cells that have the potential to trans-differentiate and contribute to the repair of other tissue types, we believe we are making unique contributions to stem cell biology and regenerative medicine.
Research Interests
Papers共 251 篇Author StatisticsCo-AuthorSimilar Experts
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Stem cells translational medicineno. 6 (2024): 532-545
Stem cell research & therapyno. 1 (2024)
bioRxiv (Cold Spring Harbor Laboratory)no. 1 (2024): 1-21
Masayuki Otani,Yoshihiro Kushida,Yasumasa Kuroda,Shohei Wakao,Yo Oguma, Keisuke Sasaki,Shintaro Katahira, Ryohei Terai,Rie Ryoke,Hiroi Nonaka,Ryuta Kawashima,Yoshikatsu Saiki,
Stroke and vascular neurology (2024)
BJU INTERNATIONALno. 3 (2024): 332-340
Yoshihiro Kushida,Yo Oguma, Kana Abe, Taichi Deguchi, Federico Girolamo Barbera,Noriyuki Nishimura,Kazumichi Fujioka,Sota Iwatani,Mari Dezawa
Journal of neurotraumano. 23-24 (2023): 2596-2609
Research Square (Research Square) (2023)
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Author Statistics
#Papers: 218
#Citation: 8943
H-Index: 48
G-Index: 89
Sociability: 6
Diversity: 4
Activity: 38
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