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Marc’s early work focused on developing techniques for studying, purifying, and characterizing what are now known as G-protein-coupled receptors (GPCRs), using the β-adrenergic receptor as a model. He also contributed greatly to the discovery of the mechanisms by which receptor signaling is regulated by kinases and β-arrestins — in particular, how the β-arrestins are involved not only in desensitization but also in endocytosis and signaling. Early on, he developed a particular interest in dopaminergic signaling, which would lead to his laboratory’s developing tools for identifying, purifying and cloning the D1 and D2 receptors and clarifying their regulation and signaling mechanisms. In a classic paper, he defined an entirely new mechanism for regulation of behavior by D2 receptor signaling through β-arrestin.
研究兴趣
论文共 810 篇作者统计合作学者相似作者
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Joshua D. Ginzel,Chaitanya R. Acharya,Veronica Lubkov,Hidetoshi Mori,Peter G. Boone,Lauren K. Rochelle,Wendy L. Roberts, Jeffrey I. Everitt, Zachary C. Hartman,Erika J. Crosby,Lawrence S. Barak,Marc G. Caron,
crossref(2023)
BIOMOLECULESno. 11 (2023): 1658-1658
Jean‐Martin Beaulieu,Emiliana Borrelli,Arvid Carlsson,Marc G. Caron,Olivier Civelli,Stefano Espinoza, Gilberto Fisone,Raul R. Gainetdinov,David K. Grandy, John W. Kebabian,Saloman Z. Langer,Maria Cristina Missale,
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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J D Gross,D W Kim,Y Zhou, D Jansen,L M Slosky, N B Clark, C R Ray,X Hu,N Southall,A Wang, X Xu, E Barnaeva,
TRENDS IN PHARMACOLOGICAL SCIENCESno. 4 (2021): 283-299
Gábor Turu,Eszter Soltész-Katona, András Dávid Tóth, Cintia Juhász,Miklós Cserző, Ádám Misák,András Balla,Marc G. Caron,László Hunyady
Frontiers in Endocrinology (2021)
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