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Bio
Research description
The anterior part of the frontal lobe in primates and rodents is referred to as the prefrontal cortex. Information processing in the PFC is considered to be central to our cognitive abilities, and to enable flexible behavior. Accordingly, disturbed PFC functioning has been connected to most, if not all, mental disorders, including drug addiction. Needless to say, deciphering of the PFC is of great importance to both understanding of the brain, and to medicine. However, the PFC still lacks a conclusive definition, and the structure and function of this brain region across species remains unresolved (Carlén M. Science 2017).
Present-day preclinical researchers increasingly utilize mice (Mus musculus) as model animals. However, clinical transfer of pre-clinically identified therapeutics targeting mental disorders (and other brain disorders) has been largely unsuccessful. Knowledge gaps regarding how the brain is built and functions contribute to the failures. Further, lack of comprehension of dissociations between species hampers the understanding of which findings are transferable from model animals to humans. Using high-density electrophysiological recordings, calcium imaging, and optogenetics in transgenic mice and rats we are in the lab characterizing cognitive processing across the subregions of the prefrontal cortex, with the goal to reveal how the prefrontal cortex enables cognition and purposeful behavior. A long-term goal is to establish defining functional features of the mammalian prefrontal cortex, which will enable evaluation of homologies between different species, and help clarify what makes the human prefrontal cortex unique.
Academic honours, awards and prizes
Wallenberg Scholar 2019
Wallenberg Academy Fellow prolongation 2017
European Research Council Starting Grant 2013 (LS5)
Wallenberg Academy Fellow in Medicine 2012
Ragnar Söderberg Fellow in Medicine 2012
2012 Freedman Prize Honorable Mention for Outstanding Research in Basic Brain and Behavior Science. Brain & Behavior Research Foundation (former NARSAD)
Sven och Ebba-Christina Hagbergs Prize 2010
NARSAD Young Investigator Award 2010
NARSAD Young Investigator Award 2008
PIIF: Picower Institute Innovation Fund 2007 (MIT; Cambridge, USA)
Keystone Symposium on Stem Cells. 2006 Scholarship
Award of Excellence: The Alzheimer’s Association Route28 Summits in Neurobiology 2001
The anterior part of the frontal lobe in primates and rodents is referred to as the prefrontal cortex. Information processing in the PFC is considered to be central to our cognitive abilities, and to enable flexible behavior. Accordingly, disturbed PFC functioning has been connected to most, if not all, mental disorders, including drug addiction. Needless to say, deciphering of the PFC is of great importance to both understanding of the brain, and to medicine. However, the PFC still lacks a conclusive definition, and the structure and function of this brain region across species remains unresolved (Carlén M. Science 2017).
Present-day preclinical researchers increasingly utilize mice (Mus musculus) as model animals. However, clinical transfer of pre-clinically identified therapeutics targeting mental disorders (and other brain disorders) has been largely unsuccessful. Knowledge gaps regarding how the brain is built and functions contribute to the failures. Further, lack of comprehension of dissociations between species hampers the understanding of which findings are transferable from model animals to humans. Using high-density electrophysiological recordings, calcium imaging, and optogenetics in transgenic mice and rats we are in the lab characterizing cognitive processing across the subregions of the prefrontal cortex, with the goal to reveal how the prefrontal cortex enables cognition and purposeful behavior. A long-term goal is to establish defining functional features of the mammalian prefrontal cortex, which will enable evaluation of homologies between different species, and help clarify what makes the human prefrontal cortex unique.
Academic honours, awards and prizes
Wallenberg Scholar 2019
Wallenberg Academy Fellow prolongation 2017
European Research Council Starting Grant 2013 (LS5)
Wallenberg Academy Fellow in Medicine 2012
Ragnar Söderberg Fellow in Medicine 2012
2012 Freedman Prize Honorable Mention for Outstanding Research in Basic Brain and Behavior Science. Brain & Behavior Research Foundation (former NARSAD)
Sven och Ebba-Christina Hagbergs Prize 2010
NARSAD Young Investigator Award 2010
NARSAD Young Investigator Award 2008
PIIF: Picower Institute Innovation Fund 2007 (MIT; Cambridge, USA)
Keystone Symposium on Stem Cells. 2006 Scholarship
Award of Excellence: The Alzheimer’s Association Route28 Summits in Neurobiology 2001
Research Interests
Papers共 44 篇Author StatisticsCo-AuthorSimilar Experts
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NATURE NEUROSCIENCEno. 7 (2023): 1245-+
Nature Neuroscienceno. 7 (2022): 1245-1255
The Journal of Neurosciencepp.1-57, (2020)
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