His researches were mainly oriented towards the study of local autocrine systems with particular interest in the role of the sympathetic cardiac system in the modulation of coronary tone in unstable angina (Neri Serneri et al. Circulation 1993) and in the early stages of the development of hypertrophy physiological athlete (NS et al. Circ Res 2001). More recently, the involvement of the sympathetic vascular arm system in the pathogenesis of Raynaud's phenomenon (Microvasc Res 2006) has been demonstrated.