基本信息
views: 153
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Dr. Bedford’s laboratory focuses on two research topics: 1) elucidating the biological role of arginine methylation – an abundant modification that has been implicated in signal transduction, transcriptional control and DNA repair, and 2) developing a protein domain microarray platform to interrogate the role of posttranslational modifications in driving protein-protein interactions in signal transduction. They have generated targeted disruptions and gain-of-function mouse models for these arginine methyltransferase enzymes, with a primary focus on CARM1. Using their protein-domain microarray platform, they have identified and characterized novel protein interactions; they have used these arrays to “read” the histone code. They have identified a number of novel proteins that interact with lysine and arginine methylated motifs, as well as with small molecules that can compete with these interactions. Recently, the Bedford lab expanded their array platform to include all the human phospho-reader domains, acetyl-reader domains, and most of the human PDZ domains and ubiquitin-binding domains.
Research Interests
Papers共 291 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Deepa Bisht,Yang Li,Lacey E. Dobrolecki,Christina Sallas,Xudong Zhang, Travis D. Kerr,Yalong Wang,Sharad Awasthi, Babita Kaundal, Siqi Wu,Weiyi Peng,Marc L. Mendillo,
Cancer Researchno. 6_Supplement (2024): 3371-3371
JOURNAL OF MOLECULAR BIOLOGYno. 7 (2024): 168371-168371
Yalong Wang,Jujun Zhou, Wei He, Rongjie Fu,Leilei Shi, Ngoc Khoi Dang,Bin Liu,Han Xu,Xiaodong Cheng,Mark T Bedford
Cell reportsno. 7 (2024): 114459-114459
SCIENCE IMMUNOLOGYno. 94 (2024): eadi1023-eadi1023
Tomer M. Yaron-Barir,Brian A. Joughin,Emily M. Huntsman,Alexander Kerelsky,Daniel M. Cizin,Benjamin M. Cohen, Amit Regev,Junho Song,Neil Vasan,Ting-Yu Lin, Jose M. Orozco,Christina Schoenherr,
NATUREno. 8014 (2024): 1-8
Tanner Wright,Yalong Wang,Sabrina A Stratton,Manu Sebastian, Bin Liu, David G Johnson,Mark T Bedford
The Biochemical journalno. 22 (2023): 1805-1816
Journal of Biological Chemistryno. 3 (2023): 104036-S558
Feng Zhu,Martijn E.T. Dollé, Thomas R. Berton,Raoul V. Kuiper, Carrie Capps,Alexsandra Espejo,Mark J. McArthur,Mark T. Bedford,Harry van Steeg,Annemieke de Vries, David G. Johnson
crossref(2023)
Cancer Researchno. 8_Supplement (2023): LB182-LB182
Feng Zhu,Martijn E.T. Dollé, Thomas R. Berton,Raoul V. Kuiper, Carrie Capps,Alexsandra Espejo,Mark J. McArthur,Mark T. Bedford,Harry van Steeg,Annemieke de Vries, David G. Johnson
crossref(2023)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn