基本信息
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职业迁徙
个人简介
We are an interdisciplinary lab focused on two major areas:(1) we seek to understand mechanisms of cancer growth and drug resistance in order to find new therapeutic targets(2) we study mechanisms by which macrophages and other cells take up diverse materials by endocytosis and phagocytosis; these substrates range from bacteria, viruses, and cancer cells to drugs and protein toxins.
In each case, the processes we study represent both fascinating basic problems in cell biology and important therapeutic targets. A complementary interest is in the characterization of novel small molecule drugs and identification of synergistic drug interactions, with the aim of finding new treatments for diseases such as cancer and neurodegeneration.
To accomplish these goals, we develop and use new technologies for high-throughput functional genomics. These include ultra-complex CRISPR/Cas9 and RNAi-based libraries for genome-wide screens, systematic pairwise genetic interaction maps, and strategies for targeted mutagenesis. We combine these techniques with microscopy, biochemistry, cell biology, and bioinformatics, tailored to each problem. Together with collaborators, we use these tools to annotate the genome in health and disease states.
In each case, the processes we study represent both fascinating basic problems in cell biology and important therapeutic targets. A complementary interest is in the characterization of novel small molecule drugs and identification of synergistic drug interactions, with the aim of finding new treatments for diseases such as cancer and neurodegeneration.
To accomplish these goals, we develop and use new technologies for high-throughput functional genomics. These include ultra-complex CRISPR/Cas9 and RNAi-based libraries for genome-wide screens, systematic pairwise genetic interaction maps, and strategies for targeted mutagenesis. We combine these techniques with microscopy, biochemistry, cell biology, and bioinformatics, tailored to each problem. Together with collaborators, we use these tools to annotate the genome in health and disease states.
研究兴趣
论文共 212 篇作者统计合作学者相似作者
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Laura Amaya, Brian Abe,Jie Liu,Feifei Zhao, Wenyan Lucy Zhang,Robert Chen,Rui Li, Steven Wang,Roarke A. Kamber,Miao-Chih Tsai,Michael C. Bassik,Ravindra Majeti,
Molecular Cell (2024)
David Yao,Josh Tycko,Jin Woo Oh, Lexi R. Bounds,Sager J. Gosai, Lazaros Lataniotis,Ava Mackay-Smith,Benjamin R. Doughty,Idan Gabdank,Henri Schmidt, Tania Guerrero-Altamirano,Keith Siklenka,
Nature Methodsno. 4 (2024): 1-12
Gaia Gentile,Teresa Poggio,Antonella Catalano, Minna Voutilainen,Mari Lahnalampi, Marta Andrade-Martinez,Tobias Ma,Roman Sankowski, Lina Goncharenko,Stefan Tholen,Kyuho Han,David W Morgens,
Blood advances (2024)
Gaia Gentile,Teresa Poggio,Antonella Catalano, Minna Voutilainen,Mari Lahnalampi, Marta Andrade-Martinez,Tobias Ma,Roman Sankowski, Lina Goncharenko,Stefan Tholen,Kyuho Han,David W. Morgens,
Blood Advances (2024)
Justin Donnelly,Roarke A Kamber,Simon Wisnovsky,David S Roberts, Egan L Peltan,Michael C Bassik,Carolyn R Bertozzi
bioRxiv : the preprint server for biology (2024)
Marta Roman Moreno,Kaja Kostyrko,Kari A. Herrington,Michael C. Bassik,Peter K. Jackson,Alejandro Sweet‐Cordero
Cancer Researchno. 7_Supplement (2023): 3920-3920
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SCIENCEno. 6658 (2023): 646-+
Andreas R Gschwind,Kristy S Mualim,Alireza Karbalayghareh, Maya U Sheth,Kushal K Dey,Evelyn Jagoda,Ramil N Nurtdinov,Wang Xi, Anthony S Tan, Hank Jones,X Rosa Ma,David Yao,
bioRxiv : the preprint server for biology (2023)
Natureno. 7956 (2023): 365-372
bioRxiv : the preprint server for biology (2023)
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