基本信息
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职业迁徙
个人简介
Research interests
Tetraspanins in health and disease
Tetraspanins are a highly conserved superfamily of transmembrane proteins, with the first member having appeared some 570 million years ago! They are widely expressed in multicellular organisms and are involved in basic cell functions such as motility, fusion and membrane trafficking. Tetraspanins form promiscuous associations with one another and with other membrane proteins and lipids to generate a specialised type of microdomain: the tetraspanin enriched microdomain (TEM). There are 33 tetraspanins in mammals with roles in fertility, the immune response, cancer progression and susceptibility to infections.
Our group uses specific antibodies and other tetraspanin-based reagents to investigate how these proteins function in health and disease. We have shown that tetraspanins help control the formation of multinucleated giant cells (MNGCs), which are associated with chronic inflammation and certain types of infection, particularly those caused by viruses.
We have also discovered that many pathogenic bacteria “hijack” tetraspanin microdomains as a way of attaching to host cells before causing infection. This has encouraged us to develop tetraspanin-based reagents as alternatives to antibiotics for treating infections caused by a wide range of microbes such as Staphylococcus aureus (including MRSA).
Antibodies in research
I have also had a long-standing interest in the production and use of antibodies as tools in research and medicine. In the early 1990s, I helped establish a dedicated facility at the University for Custom Production of antibodies for researchers. A related spinout company, Bioserv UK Ltd, established in 2009, specialises in the production of antibodies and other proteins from mammalian cell culture.
研究兴趣
论文共 57 篇作者统计合作学者相似作者
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The ocular surface (2023): 211-218
Jiajia Ma,Claire A. Scott,Ying Na Ho,Harsha Mahabaleshwar,Katherine S. Marsay,Changqing Zhang, Christopher Kj Teow, Ser Sue Ng,Weibin Zhang,Vinay Tergaonkar,Lynda J. Partridge,Sudipto Roy,
Access Microbiologyno. 7A (2020)
Medical Microbiology and Immunologyno. 5 (2020): 643-652
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作者统计
#Papers: 57
#Citation: 1102
H-Index: 23
G-Index: 32
Sociability: 5
Diversity: 2
Activity: 9
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