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Deregulated signaling pathways in cancer cells drive tumorigenesis and dictate drug responses. These changes in signaling can be caused by genomic aberrations (e.g. gene mutation or copy number variation) or non-genetic network rewiring. Targeting the alterations can be effective anticancer strategies.
The overall goal of the laboratory is to identify potential molecular targets for cancer therapies. Our major focus areas include:
Exploring novel genome-informed therapeutic approaches. We are dedicated to: i) characterize driver genomic aberrations and the associated signaling cascades; ii) determine the therapeutic vulnerability engendered by the aberrations; and iii) identify predictive markers of therapeutic responses.
Deriving strategies to overcome cancer drug resistance. We investigate the molecular mechanisms by which cancer cells become resistant to pathway inhibitors.
The overall goal of the laboratory is to identify potential molecular targets for cancer therapies. Our major focus areas include:
Exploring novel genome-informed therapeutic approaches. We are dedicated to: i) characterize driver genomic aberrations and the associated signaling cascades; ii) determine the therapeutic vulnerability engendered by the aberrations; and iii) identify predictive markers of therapeutic responses.
Deriving strategies to overcome cancer drug resistance. We investigate the molecular mechanisms by which cancer cells become resistant to pathway inhibitors.
Research Interests
Papers共 64 篇Author StatisticsCo-AuthorSimilar Experts
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期刊级别
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合作机构
Safia S Aljedani,Abdullah Aldehaiman, Anandsukeerthi Sandholu,Siba Alharbi,Victor C Y Mak, Haiyan Wu,Adrien Lugari,Mariusz Jaremko,Xavier Morelli,Jonathan W Backer,John E Ladbury,Michał Nowakowski,
bioRxiv : the preprint server for biology (2024)
Cancer Researchno. 7_Supplement (2023): 2563-2563
Science advancesno. 47 (2023): eadj0123-eadj0123
CANCER RESEARCHno. 7 (2023)
Xiaoran Long,Huaiwu Lu,Mei-Chun Cai,Jingyu Zang, Zhuqing Zhang, Jie Wu,Xiaoshi Liu,Lin Cheng,Jiejun Cheng,Lydia W. T. Cheung,Zhen Shen,Ying Zhou,
BRITISH JOURNAL OF CANCERno. 11 (2023): 2054-2062
CANCER RESEARCHno. 7 (2023)
Aya El Helali,Tai-Chung Lam, Elaine Yee-Ling Ko,David J H Shih, Chun Kau Chan,Charlene H L Wong,Jason W H Wong,Lydia W T Cheung, Johnny K S Lau,Anthony P Y Liu,Ann S Y Chan,Herbert H Loong,
Cancer Researchno. 7_Supplement (2023): 2553-2553
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Author Statistics
#Papers: 57
#Citation: 1987
H-Index: 21
G-Index: 44
Sociability: 6
Diversity: 0
Activity: 1
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