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个人简介
During my PhD training (1998-2003) at Karolinska Institutet my research focused on projects to develop dendritic cell (DC) vaccines against cancer. During this period I authored 10 original research articles and two review articles. We developed protocols for the manufacture of clinical-grade DC-based therapeutic vaccines. Specifically, we investigated how different antigen-loading approaches affected the ability of DC to prime anti-tumor T cell responses. We determined crucial components and characterized mechanistic pathways for developing optimal DC-based vaccines against cancer. Discoveries made during my PhD training lead to the design of a clinical pilot trial and these discoveries are still being implemented in clinical trials at Karolinska Institutet today.
During my post-doctoral tenure (2003-2008) at the National Institutes of Health (NIH) my research focused on developing natural killer (NK) cell therapies against cancer. We developed animal models and used patient material to study how to augment NK cell activity against cancer in both allogeneic and autologous hosts. During this period I published 18 original research articles and three review articles. Four years into my tenure at the NIH I received a bench-to-bedside award and was promoted to a staff scientist at the Hematology Branch to establish an independent research program. In 2008, we commenced on the first-in-man clinical trial on adoptive infusion of ex vivo expanded autologous NK cells in patients with cancer.
In October of 2009, I returned to Karolinska Institutet to establish my own laboratory. My research group focuses on to develop improved immunotherapy treatments as well as prognostic and predictive biomarkers in patients with cancer. We currently investigate how to augment lymphocyte migration toward tumors, the ability of lymphocytes to kill tumor targets, and the regulation of lymphocyte activity in the tumor microenvironment.
研究兴趣
论文共 224 篇作者统计合作学者相似作者
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Journal of experimental & clinical cancer research : CRno. 1 (2024): 13-13
Shi Yong Neo,Le Tong, Joni Chong, Yaxuan Liu,Xu Jing,Mariana M. S. Oliveira,Yi Chen,Ziqing Chen, Keene Lee, Nutsa Burduli,Xinsong Chen,Juan Gao,
Science Translational Medicineno. 747 (2024)
Shi Yong Neo,Le Tong, Joni Chong, Yaxuan Liu,Xu Jing,Mariana M S Oliveira,Yi Chen,Ziqing Chen, Keene Lee, Nutsa Burduli,Xinsong Chen,Juan Gao,
Science translational medicineno. 747 (2024): eadi2952-eadi2952
Oncoimmunologyno. 1 (2024): 2372875-2372875
Pedro Fonseca, Weiyingqi Cui, Nona Struyf,Le Tong, Ayushi Chaurasiya, Felipe Casagrande,Honglei Zhao, Dinura Fernando,Xinsong Chen,Nicholas P. Tobin, Brinton Seashore-Ludlow,Andreas Lundqvist,
CANCER RESEARCHno. 7 (2023)
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