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个人简介
Rodriguez-Lorenzo completed his doctoral studies in biomaterials in 1999 at UCM. After a postdoctoral period at Monash University, in Australia, carrying out projects related with osseointegration of total hip prostheses by chemical modification of their coatings and the preparation of supports for tissue engineering, he joined ICTP–CSIC, Spain in 2004. His expertise is the preparation and optimization of materials, scaffolds and constructs for tissue engineering. This involves the synthesis of new materials and the development of processing techniques for these materials and the testing of the suitability for the designed application.
Rodríguez-Lorenzo has a background working in both ceramic and polymeric materials for biomedical applications. In the area of ceramics have worked mainly with hydroxyapatites. The synthesis of functionalized nano and microparticles of hydroxyapatite with relevant ionic substitutions for improving the biological response from a host have been developed achieving osteoinductive hydroxyapatites with modulation of resorbability and mechanical properties. In the polymer area, synthesis methods for gels and cryogels based on 2-(Dimethylamino)ethyl Methacrylate, (2-Hydroxyethyl)Methacrylate or Thiol-Acrylate PolyHIPE able to be infiltrated by MSC have been developed. The sol-gel process has also been studied for the production of titania/polyurethanes or silica/polysaccharides hybrids enabling the sol-gel process as a new procedure to develop bioinks suitable for 3D bioprinting. Processing techniques assayed include colloidal processing of dense ceramics and development of methods for producing porous ceramics such as starch consolidation or infilling and removal of natural porous materials including sodium chloride, polyurethanes or wood. Other methods for processing porous polymeric methods assayed are spinoidal decomposition, freeze drying, cryopolymerization and electrospinning. For the last 5 years, the activity in the area of processing materials has focused in the manufacturing of porous scaffolds with 3D printing and constructs containing biological material through bioprinting. The parameters affecting the host response to the material, protein adhesion and suitable degradation kinetics were optimized. Controlled release of active substances though superficial chemical properties was achieved. The combination of these areas of study led to the preparation of devices with an appropriate balance of mechanical and superficial properties that allow the invasion and ingrowth of mesenchymal stem cells for bone engineering. Bioinks optimization and bioprinting conditions for the production of tumor models have also been developed during the last 3 years. All these works have been presented in 107 communications in international congress, 17 national congress and 18 invited conferences and produced the following publications and impact.
01-08-23
Pubs. Number; Cites / per article ; h / i10 indexes; Pubs in Q1
WoS (Clarivate) 68; 2135 / 31,4; 24; 37/66
Scopus (Elsevier) 76; 2413 / 31,75; 25; 44/72
Google Scholar: 100; 3120 / 31,2; 27 / 41 ; -
9 PhD dissertations have been supervised since 2010. Dr Rodrigo Jimenez (2010) is today Profesor-Investigador, director of SIP projects and head of “Unidad Politécnica de Integración-ESIQIE at IPN, CDMX, Mexico. Dr: Nancy Vargas belongs to SNI (México) level 1 and is a researcher at Condensed matter department at UNAM (Mexico). Javier Quintana is MD, PhD and MBA is today a senior Health Economics and Market access manager & HEMA lead at Johnson & Johnson, Spain, Angelica Lara is docente investigadora, Genoma group at medicine faculty, Universidad del Sinú – Cartagena- Colombia. Dulce García is lecturing polymers at La Salle Unversity, México and Project analyst at IPN, CDMX, Mexico. Daniela Sanchez is Junior researcher at INDR-IPN, Mexico. Aurora Hernandez is a Postdoc at IPN and Nieves Cubo is Associate professor at Universidad Nebrija.
研究兴趣
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FRONTIERS IN PHARMACOLOGY (2024): 1369505-1369505
Cristina Banda Sanchez,Nieves Cubo Mateo,Laura Saldana,Alba Valdivieso,Julie Earl, Itziar Gonzalez Gomez,Luis M. Rodriguez-Lorenzo
Leila Maestro-Paramio,Eduardo García-Rey, Fátima Bensiamar,Luís M. Rodríguez‐Lorenzo,Nuria Vilaboa,Laura Saldaña
Orthopaedic Proceedingsno. SUPP_7 (2023): 70-70
Itziar Gonzalez,Jon Luzuriaga,Alba Valdivieso, Manuel Candil,Jesus Frutos, Jaime Lopez,Luis Hernandez,Luis Rodriguez-Lorenzo, Virginia Yaguee,Jose Luis Blanco,Alberto Pinto,Julie Earl
Polymersno. 10 (2023): 2299-2299
Itziar González,Jon Luzuriaga,Alba Valdivieso, Jesús Frutos, Jaime López,Luis Hernández,Luis Rodríguez-Lorenzo, Virginia Yagüe,Jose Luis Blanco,Alberto Pinto,Julie Earl
Research Square (Research Square) (2021)
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