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My laboratory studies the signaling pathways that control vertebrate neural development and that go awry in tumorigenesis. One focus has been the Trk family of transmembrane RTK receptors for the neurotrophin ligands. Using knockout mutations in mice for the genes encoding the neurotrophins: BDNF, NT3, and NT4/5, as well as the TrkA and TrkB receptors, we studied the essential nature of the neurotrophins and their receptors in the survival of early neurons and more complex phenotypes in the central and peripheral nervous systems. Conditional knockout technology allowed for more precise analysis of neurotrophin function in the CNS, demonstrating a role in development, synaptic plasticity and behavior. These models also proved useful for studying neuropsychiatric disorders, including depression, and we are currently investigating the role of hippocampal neurogenesis in antidepressant response.
Research Interests
Papers共 375 篇Author StatisticsCo-AuthorSimilar Experts
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Laura Biddlestone-Thorpe, Muhammad Sajjad,Elizabeth Rosenberg,Jason M. Beckta,Nicholas C.K. Valerie, Mary Tokarz,Bret R. Adams,Alison F. Wagner,Ashraf Khalil,Donna Gilfor,Sarah E. Golding,Sumitra Deb,
crossref(2023)
crossref(2023)
Neuro-oncologyno. Supplement_1 (2023): i11-i11
Proceedings of the National Academy of Sciences of the United States of Americano. 16 (2023)
Thu P. Nguyen,Wentian Wang,Alex C. Sternisha,Chase D. Corley, Hua-Yu Leo Wang, Xiaoyu Wang,Francisco Ortiz, Sang-Kyun Lim,Kalil G. Abdullah,Luis F. Parada,Noelle S. Williams,Samuel K. McBrayer,
NEURO-ONCOLOGY (2023)
Chang-Hyuk Kwon,Dawen Zhao,Jian Chen, Sheila Alcantara, Yanjiao Li,Dennis K. Burns,Ralph P. Mason,Eva Y.-H. P. Lee,Hong Wu,Luis F. Parada
crossref(2023)
crossref(2023)
crossref(2023)
Cancer Researchno. 12_Supplement (2022)
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