The focus of our research is in the field of analytical chemistry, with particular interest on separation science. Our research group develops chromatographic media for chemical separations, detection schemes for monitoring mass-limited samples (i.e., micro scale), study the use of nanotechnology in separations, and develops new strategies to separate and analyze complex chemical or biochemical sample mixtures, such as biofluids, intracellular components, protein digests, and pharmaceutical drugs, among others. One current research effort is centered on the synthesis and physicochemical characterization and chromatographic behavior of new separation media for chromatography. Our chromatographic materials are synthesized in different formats (i.e., particles, thin films, and monoliths), which are suitable for HPLC, supercritical fluid chromatography (SFC), and solid phase extraction. An example is the synthesis of fluorinated phases that can impart unique selectivity in the separation and isolation of fluorine-containing compounds (e.g., PFAS). We also use various separation techniques (e.g., SFC, LC/MS, LC/ICP/MS) to analyze environmentally relevant samples (e.g., food, fresh water, and supplements) or of biological origin (e.g., saliva, cell lysates, and tear fluid). The latter sample type allows us to explore the potential of such fluids as a mean to sample chemical species suitable for clinical analysis/diagnosis. Our efforts have impact in many areas; some examples include the environmental, biomedical, and the pharmaceutical fields.