基本信息
views: 12
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Our laboratory's interests are in the physiology of brain systems that regulate energy balance (appetite, body weight, blood glucose). Neurones in integratory centres of the brain combine synaptic inputs, including those that relay sensory and emotional information, with endocrine inputs, including feedback from circulating hormones and nutrients. Outputs from these centres then drive regulatory responses by other peripheral organs, such as the liver, pancreas and adipose tissue. An understanding of these pathways may reveal novel sites for future therapeutic intervention in diseased states, such as obesity and diabetes. This biology requires a multidisciplinary approach covering brain connectivity, signal detection and transduction, gene identification and expression, neuronal output and finally behaviour.
Recently we have provided evidence for the existence of new pathways that can integrate short-term satiety signals from the gut and brainstem, or circulating nutrients, with longer-term regulators of body weight located in the hypothalamus. We are investigating how whole brain circuits involved in homeostasis and reward respond to different stimuli depending on state and how this relates to the development of metabolic diseases. We are particularly interested in how the expression of the genome reflects the current obesogenic environment.
Recently we have provided evidence for the existence of new pathways that can integrate short-term satiety signals from the gut and brainstem, or circulating nutrients, with longer-term regulators of body weight located in the hypothalamus. We are investigating how whole brain circuits involved in homeostasis and reward respond to different stimuli depending on state and how this relates to the development of metabolic diseases. We are particularly interested in how the expression of the genome reflects the current obesogenic environment.
Research Interests
Papers共 18 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Nature communicationsno. 1 (2023): 1450-1450
Molecular metabolism (2021): 101407-101407
ENDOCRINOLOGYno. 2 (2010): 771-777
mag(2007)
Creemers John W M,Pritchard Lynn E, Gyte Amy, Le Rouzic Philippe,Meulemans Sandra,Wardlaw Sharon L,Zhu Xiaorong,Steiner Donald F,Davies Nicola,Armstrong Duncan,Lawrence Catherine B,Luckman Simon M,
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn