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The long-term goal of my research is to understand the cellular and molecular mechanisms that underlie synapse function during behavior in the developing and mature brain, and how synapse function is altered during mental retardation. In this broad research area, I am specifically interested in the homeostatic control of synaptic strength, the role of postsynaptic protein translation in this control, and the impairment of synapses in Fragile X syndrome that involves changes in postsynaptic protein translation and synaptic strength.
We recently discovered a role of all-trans retinoic acid (RA) in regulating synapse formation and synaptic strength, which we identified during studies of homeostatic synaptic plasticity. We found that RA is a potent activator of synaptic strength in mature neurons. Neuronal synthesis of RA is regulated by activity. When neuronal activity is blocked, RA synthesis is strongly stimulated. When applied directly, RA is sufficient to rapidly increase synaptic strength. Moreover, when we blocked RA synthesis in neurons, we abolished the increase in synaptic strength induced by activity blockade. Taken together, these results reveal a central role of RA in mediating activity blockade-induced increases in synaptic strength, and suggest that in adult brain, RA functions as a novel diffusible messenger that regulates synaptic transmission.
We recently discovered a role of all-trans retinoic acid (RA) in regulating synapse formation and synaptic strength, which we identified during studies of homeostatic synaptic plasticity. We found that RA is a potent activator of synaptic strength in mature neurons. Neuronal synthesis of RA is regulated by activity. When neuronal activity is blocked, RA synthesis is strongly stimulated. When applied directly, RA is sufficient to rapidly increase synaptic strength. Moreover, when we blocked RA synthesis in neurons, we abolished the increase in synaptic strength induced by activity blockade. Taken together, these results reveal a central role of RA in mediating activity blockade-induced increases in synaptic strength, and suggest that in adult brain, RA functions as a novel diffusible messenger that regulates synaptic transmission.
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Frontier Media SA eBooks (2023)
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Lu Chen,Caitlin M Roake,Paolo Maccallini,Francesca Bavasso,Roozbeh Dehghannasiri,Pamela Santonicola, Natalia Mendoza-Ferreira,Livia Scatolini, Ludovico Rizzuti, Alessandro Esposito,Ivan Gallotta,Sofia Francia,
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2022)
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