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Research Description
The main focus of my research is host and pathogen interactions using amphibian model systems. Our work also falls into the category of Eco-Immunology. Currently, my laboratory is pursuing a number of questions concerning the nature of innate and adaptive immune defenses in frog skin against two novel chytrid pathogens linked to global amphibian declines. Understanding the immune defense mechanisms of amphibians has taken on increased importance in recent years because of the urgent problem of global amphibian declines. Little is known about the conventional adaptive immune response against Batrachochytrium dendrobatidis (Bd) and a recently discovered closely related chytrid Batrachochytrium salamandrivorans (Bsal). Our ongoing studies have shown that Bd releases factors which inhibit lymphocyte responses. Preliminary studies suggest that Bsal also releases factors that inhibit immunity. Current research investigates the specific mechanisms by which these fungi may escape immunity. Another focus of my research is the study of antimicrobial peptides in frog skin in defense against bacterial, viral, and fungal pathogens. Currently, we are using growth inhibition assays to test the ability of purified antimicrobial peptides to interfere with growth of specific pathogens that have been associated with global amphibian declines. Another newer area of research is the effects of temperature on immune defenses of local Tennessee amphibians. This relates to the question of how climate change may impact southern amphibians. With collaborators, we are also studying the role of skin microbiota as protectors of amphibians from Bd and Bsal.
The main focus of my research is host and pathogen interactions using amphibian model systems. Our work also falls into the category of Eco-Immunology. Currently, my laboratory is pursuing a number of questions concerning the nature of innate and adaptive immune defenses in frog skin against two novel chytrid pathogens linked to global amphibian declines. Understanding the immune defense mechanisms of amphibians has taken on increased importance in recent years because of the urgent problem of global amphibian declines. Little is known about the conventional adaptive immune response against Batrachochytrium dendrobatidis (Bd) and a recently discovered closely related chytrid Batrachochytrium salamandrivorans (Bsal). Our ongoing studies have shown that Bd releases factors which inhibit lymphocyte responses. Preliminary studies suggest that Bsal also releases factors that inhibit immunity. Current research investigates the specific mechanisms by which these fungi may escape immunity. Another focus of my research is the study of antimicrobial peptides in frog skin in defense against bacterial, viral, and fungal pathogens. Currently, we are using growth inhibition assays to test the ability of purified antimicrobial peptides to interfere with growth of specific pathogens that have been associated with global amphibian declines. Another newer area of research is the effects of temperature on immune defenses of local Tennessee amphibians. This relates to the question of how climate change may impact southern amphibians. With collaborators, we are also studying the role of skin microbiota as protectors of amphibians from Bd and Bsal.
Research Interests
Papers共 176 篇Author StatisticsCo-AuthorSimilar Experts
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Sarah A R Schrock, Jason C Walsman,Joseph DeMarchi, Emily H LeSage,Michel E B Ohmer,Louise A Rollins-Smith,Cheryl J Briggs,Corinne L Richards-Zawacki,Douglas C Woodhams,Roland A Knapp,Thomas C Smith,Célio F B Haddad,C Guilherme Becker,Pieter T J Johnson,Mark Q Wilber
Proceedings Biological sciencesno. 2043 (2025): 20242013-20242013
Douglas C. Woodhams, Aura Muñiz-Torres,Andreas Hertz,Patrick Kearns, Nina McDonnell,Laura Reinert,Louise A. Rollins-Smith,Brandon LaBumbard,Jamie Voyles,Corinne L. Richards-Zawacki, Daniel Callahan, J. Michael Conlon
Frontiers in Amphibian and Reptile Science (2024)
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2024)
Deanna H. Olson,Evan H. Campbell Grant,Molly Bletz,Jonah Piovia-Scott,David Lesbarrères,Jacob L. Kerby,Michael J. Adams, Maria Florencia Breitman, Michelle R. Christman,María J. Forzán,Matthew J. Gray,Aubree J. Hill,Michelle S. Koo, Olga Milenkaya,Eria A. Rebollar,Louise A. Rollins-Smith,Megan Serr,Alexander Shepack,Leonard Shirose, Laura Sprague,Jenifer B. Walke,Alexa R. Warwick,Brittany A. Mosher
Frontiers in Amphibian and Reptile Science (2024)
Kelsey A. Hauser,Christina N. Garvey,Ryley S. Crow, Muhammad R. H. Hossainey, Dustin T. Howard, Netra Ranganathan, Lindsey K. Gentry,Amulya Yaparla,Namarta Kalia,Mira Zelle, Elizabeth J. Jones,Anju N. Duttargi,Louise A. Rollins-Smith,Carly R. Muletz-Wolz,Leon Grayfer
ELIFE (2024)
Cheryl Briggs, Michel Ohmer, Emily Le-Sage,Mark Wilber, Corinne Richards-Zawacki, Joe DeMarchi,Louise Rollins-Smith,Jamie Voyles
INTEGRATIVE AND COMPARATIVE BIOLOGY (2024): S62-S62
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Kelsey A. Hauser,Christina N. Garvey,Ryley S Crow,Muhammad Riadul Haque Hossainey, Dustin T Howard, Natarajan Ranganathan, Lindsey K Gentry,Amulya Yaparla,Namarta Kalia,Mira Zelle, E. Grant Jones,Anju Duttargi,Louise A. Rollins‐Smith,Carly R. Muletz‐Wolz,Leon Grayfer
eLife (2024)
Integrative and Comparative Biology (2024)
Michel Ohmer, Emily Le-Sage,Mark Wilber, Allie Byrne,Brandon LaBumbard, Karie Altman, Nina McDonnell,Veronica Saenz, Ian Latella, Laura Brannelly, Cheryl Briggs,Jamie Voyles,Louise Rollins-Smith, Douglas Woodhams, Corinne Richards-Zawacki
INTEGRATIVE AND COMPARATIVE BIOLOGY (2024): S381-S381
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Emily Le-Sage,Brandon LaBumbard, Michel Ohmer,Laura Reinert, Karie Altman, Nina McDonnell, Ian Latella,Veronica Saenz,Mark Wilber,Jamie Voyles, Douglas Woodhams, Corinne Richards-Zawacki,Louise Rollins-Smith
INTEGRATIVE AND COMPARATIVE BIOLOGY (2024): S292-S293
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Author Statistics
#Papers: 176
#Citation: 8798
H-Index: 51
G-Index: 91
Sociability: 6
Diversity: 4
Activity: 16
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