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Research Description
The main focus of my research is host and pathogen interactions using amphibian model systems. Our work also falls into the category of Eco-Immunology. Currently, my laboratory is pursuing a number of questions concerning the nature of innate and adaptive immune defenses in frog skin against two novel chytrid pathogens linked to global amphibian declines. Understanding the immune defense mechanisms of amphibians has taken on increased importance in recent years because of the urgent problem of global amphibian declines. Little is known about the conventional adaptive immune response against Batrachochytrium dendrobatidis (Bd) and a recently discovered closely related chytrid Batrachochytrium salamandrivorans (Bsal). Our ongoing studies have shown that Bd releases factors which inhibit lymphocyte responses. Preliminary studies suggest that Bsal also releases factors that inhibit immunity. Current research investigates the specific mechanisms by which these fungi may escape immunity. Another focus of my research is the study of antimicrobial peptides in frog skin in defense against bacterial, viral, and fungal pathogens. Currently, we are using growth inhibition assays to test the ability of purified antimicrobial peptides to interfere with growth of specific pathogens that have been associated with global amphibian declines. Another newer area of research is the effects of temperature on immune defenses of local Tennessee amphibians. This relates to the question of how climate change may impact southern amphibians. With collaborators, we are also studying the role of skin microbiota as protectors of amphibians from Bd and Bsal.
The main focus of my research is host and pathogen interactions using amphibian model systems. Our work also falls into the category of Eco-Immunology. Currently, my laboratory is pursuing a number of questions concerning the nature of innate and adaptive immune defenses in frog skin against two novel chytrid pathogens linked to global amphibian declines. Understanding the immune defense mechanisms of amphibians has taken on increased importance in recent years because of the urgent problem of global amphibian declines. Little is known about the conventional adaptive immune response against Batrachochytrium dendrobatidis (Bd) and a recently discovered closely related chytrid Batrachochytrium salamandrivorans (Bsal). Our ongoing studies have shown that Bd releases factors which inhibit lymphocyte responses. Preliminary studies suggest that Bsal also releases factors that inhibit immunity. Current research investigates the specific mechanisms by which these fungi may escape immunity. Another focus of my research is the study of antimicrobial peptides in frog skin in defense against bacterial, viral, and fungal pathogens. Currently, we are using growth inhibition assays to test the ability of purified antimicrobial peptides to interfere with growth of specific pathogens that have been associated with global amphibian declines. Another newer area of research is the effects of temperature on immune defenses of local Tennessee amphibians. This relates to the question of how climate change may impact southern amphibians. With collaborators, we are also studying the role of skin microbiota as protectors of amphibians from Bd and Bsal.
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论文共 128 篇作者统计合作学者相似作者
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Deanna H. Olson,Evan H. Campbell Grant,Molly Bletz,Molly Bletz,Jonah Piovia-Scott,David Lesbarrères,Jacob L. Kerby,Michael J. Adams, Maria Florencia Breitman, Michelle R. Christman,María J. Forzán,Matthew J. Gray,
Frontiers in Amphibian and Reptile Science (2024)
Developmental & Comparative Immunology (2024): 105237-105237
Zuania Colon-Pineiro, Junangel Aleman-Rios,Laura Reinert,Louise Rollins-Smith,Patricia Burrowes,Ana Longo
INTEGRATIVE AND COMPARATIVE BIOLOGY (2023): S91-S91
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Philosophical transactions of the Royal Society of London. Series B, Biological sciencesno. 1882 (2023): 20220132
Elena N Pokidysheva, Neve Redhair, Octavia Ailsworth,Patrick Page-McCaw,Louise Rollins-Smith, Vijayishwer Singh Jamwal,Yuko Ohta,Hans Peter Bächinger,Prayag Murawala,Martin Flajnik,Agnes B Fogo,Dale Abrahamson,
Kelsey A. Hauser, Muhammad R. H. Hossainey, Lindsey K. Gentry,Christina N. Garvey, Netra Ranganathan,Amulya Yaparla,Namarta Kalia,Mira Zelle, Elizabeth J. Jones,Anju N. Duttargi,Louise A. Rollins-Smith,Carly R. Muletz-Wolz,
crossref(2023)
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作者统计
#Papers: 130
#Citation: 7352
H-Index: 45
G-Index: 84
Sociability: 6
Diversity: 4
Activity: 38
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