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Research Narrative
The Louis laboratory has investigated the molecular basis of malignant gliomas for the past approximately 30 years, with the long-term goal being to devise molecular diagnostic approaches to glioma classification and therapy.
Initially, the group demonstrated alterations characteristic of specific glioma subtypes and grades and originally demonstrated that molecular genetic analysis could be used to define clinicopathologically relevant subsets of glioblastomas. The laboratory then showed that molecular genetic alterations are powerful predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas; these findings have already led to clinical applications, with molecular testing for 1p and 19q status available worldwide.
The Louis laboratory has investigated the molecular basis of malignant gliomas for the past approximately 30 years, with the long-term goal being to devise molecular diagnostic approaches to glioma classification and therapy.
Initially, the group demonstrated alterations characteristic of specific glioma subtypes and grades and originally demonstrated that molecular genetic analysis could be used to define clinicopathologically relevant subsets of glioblastomas. The laboratory then showed that molecular genetic alterations are powerful predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas; these findings have already led to clinical applications, with molecular testing for 1p and 19q status available worldwide.
Research Interests
Papers共 109 篇Author StatisticsCo-AuthorSimilar Experts
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Yael Gernez,Mansi Narula,Alma-Martina Cepika,Juanita Valdes Camacho,Elisabeth G Hoyte, Kirsten Mouradian, Bertil Glader,Deepika Singh,Bindu Sathi, Latha Rao, Ana L Tolin,Kenneth I Weinberg,
Frontiers in immunology (2024): 1328005-1328005
Avery's Diseases of the Newbornpp.409-438.e8, (2024)
Brain pathology (Zurich, Switzerland)no. 2 (2023): e13183-e13183
The Journal of Allergy and Clinical Immunology: In Practice (2022)
The Journal of Allergy and Clinical Immunology: In Practiceno. 5 (2022): 1385-1388.e2
biorxiv(2022)
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