Over her career, she has developed and assessed predictive models for diseases such as autoimmune diseases, HIV and pre-natal screening and continues to apply her methods to complex diseases. Her current research focuses primarily on genetics and genomics of Alzheimer’s Disease and dementia with an emphasis on longitudinal cohorts and cognition. She serves as the co-lead of the Data and Statistics Core of the Massachusetts Alzheimer’s Disease Research Center (MADRC) and Director of the Biostatistical Consulting Service in the Dept. of Neurology.

In addition to her research, she is internationally renowned for her training programs and innovative teaching techniques, having developed multiple courses in biostatistics for varied audiences, most recently a series specific to the needs of scientists in sub-Saharan Africa. Currently she directs the Global Initiative for Neuropsychiatric Genetics Education and Research (GINGER) program at the Harvard-Chan School and the Broad Institute of MIT and Harvard.