基本信息
浏览量:17
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
We have been studying the core mechanisms that govern differentiation and tissue-specific gene expression of epithelia. They comprise those dictated by the epithelial-mesenchymal cell-cell relationships and those defined by stem cell and maturational lineage biology. The epithelial-mesenchymal cell-cell relationships are driven by synergistic effects of soluble signals (autocrine, paracrine, endocrine) with the effects of the extracellular matrix, an insoluble complex of collagens, adhesion molecules, proteoglycans and factors bound to these matrix components. Tissue-specific gene expression is mediated by matrix-hormone/growth factor synergistic effect. Most of these influence posttranscriptional regulatory mechanisms (translation, mRNA stability, protein stability, etc.). Transcriptional regulation is governed primarily by soluble signals in combination with proteoglycans and more specifically with those soluble signals in combination with defined epitopes of the proteoglycan’s glycosaminoglycan (GAG) chains. The most potent of these GAG chains are forms of heparins with specific sulfation patterns.
研究兴趣
论文共 40 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Matrix biology : journal of the International Society for Matrix Biology (2024): 59-59
crossref(2023)
Wencheng Zhang,Xicheng Wang,Giacomo Lanzoni,Eliane Wauthier,Sean Simpson,Jennifer Ashley Ezzell,Amanda Allen,Carolyn Suitt, Jonah Krolik, Alexander Jhirad,Juan Dominguez-Bendala,Vincenzo Cardinale,
Matrix biology : journal of the International Society for Matrix Biology (2023): 194-216
CANCER RESEARCH COMMUNICATIONSno. 7 (2022): 663-678
crossref(2022)
Journal of tissue engineering (2020): 2041731420972310-2041731420972310
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn