基本信息
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Bio
Dr. Smith's research accomplishments include the development and standardization of the mouse model of oxygen-induced retinopathy; basic mechanisms of vascular growth and translation to the clinic via VEGF; growth hormone and insulin-like growth factor in retinopathy; the role of omega-3 and omega-6 polyunsaturated fatty acids and other lipids in photoreceptor metabolism driving angiogenesis; and photoreceptor energy deficiency as cause of neovascular AMD. Dr. Smith's notable recent accomplishments include development of mitochondrial functional mapping of the retina and optic nerve; development of FGF21 as a treatment for diseases with depressed mitochondrial function, including retinal degenerations (retinitis pigmentosa), AMD, diabetic retinopathy, and ROP; the development of GPR40 and GPR120 as targets for improving mitochondrial function in disease; and SOCS3 as a modulator of inflammation in photoreceptor signaling.
Research Interests
Papers共 449 篇Author StatisticsCo-AuthorSimilar Experts
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International journal of molecular sciencesno. 10 (2024): 5503
Clinical Nutritionno. 5 (2024): 1162-1170
Austin T. Gregg, Tianxi Wang,Manon Szczepan, Enton Lam, Hitomi Yagi, Katherine Neilsen, Xingyan Wang,Lois E. H. Smith,Ye Sun
Angiogenesispp.1-12, (2024)
Ann Hellström,Elsa Kermorvant-Duchemin, Mark Johnson,Miguel Sáenz de Pipaón,Lois E Smith,Anna-Lena Hård, ESPR Nutrition council members
Hitomi Yagi, Myriam Boeck, Mariya Petrishka-Lozenska,Pia Lundgren, Taku Kasai, Gael Cagnone, Chaomei Wang, Jeff Lee, Yohei Tomita,Sasha A Singh,Jean-Sébastien Joyal,Masanori Aikawa,
Research square (2024)
The Lancet Regional Health - Europe (2023): 100696-100696
The American journal of clinical nutritionno. 3 (2023): 579-590
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