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Bio
His interests changed to glycerophospholipid metabolism in the late 1960s when he became interested in composition of myelin and demyelinating diseases. He developed methods for the separation of, and characterization of, phospholipid molecular species from brain tissue. He was well known for his pioneering studies on the metabolism and role of plasmalogen in brain. This included work using fluorometric and spectrophotometric assay methods to determine the presence and activity of plasmalogen-selective-phospholipase A2 and lysoplasmalogenase in the brain. He not only discovered plasmalogen-selective phospholipase A2 in brain but also described the stimulation of cytosolic phospholipase A2 and plasmalogen-selective phospholipase A2 in Alzheimer’s disease. Stimulation of these enzymes is responsible for the decrease in plasmalogen levels and increase in phosphomonoesters and phosphodiesters in brain tissue from AD patients. He was the first to describe the stimulation of phospholipase A2 in ischemic injury and patented the use of CDP-ethanolamine and CDP-choline as a therapy for treating ischemic brain injury. Dr Horrocks also extended his work in neurotrauma to the mechanisms underlying the pathophysiology of spinal cord injury and was the first to note that polyunsaturated fatty acids and eicosanoids are released during and following injury, accompanied by a reduction in plasmalogen and cholesterol levels following spinal cord injury. This was a critical observation in that it formed the biochemical basis for the use of methylprednisolone as a treatment for spinal cord injury.
Research Interests
Papers共 39 篇Author StatisticsCo-AuthorSimilar Experts
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Molecular and chemical neuropathologyno. 2 (1995): 155-173
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Author Statistics
#Papers: 35
#Citation: 1292
H-Index: 18
G-Index: 35
Sociability: 4
Diversity: 1
Activity: 0
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