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个人简介
Research in our laboratory centers on the identification of biosignatures for psychiatric disorders and the antidepressant drug response. Sensitive, high-throughput proteomics and metabolomics platforms are used for data generation providing a rich source for in silico pathway analyses. Our ultimate goal is to complement imprecise DSM-based clinical parameters with molecular biosignatures to improve patient diagnosis, stratification and treatment.
Discovery of affected molecular pathways in mouse models that represent defined endophenotypes characteristic for human psychiatric disorders including anxiety, posttraumatic stress disorder and schizophrenia.
Drugs that target the monoaminergic (SSRI) and glutamatergic (Ketamine) systems studied in mice with the goal to delineate mechanisms relevant for the therapeutic response and novel drug targets.
Clinical translation with the help of psychiatric patient specimens collected in our hospital.
研究兴趣
论文共 181 篇作者统计合作学者相似作者
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Ipsita Mohanty,Helena Mannochio-Russo, Joshua V. Schweer,Yasin El Abiead,Wout Bittremieux,Shipei Xing,Robin Schmid,Simone Zuffa, Felipe Vasquez, Valentina B. Muti,Jasmine Zemlin,Omar E. Tovar-Herrera,
Jianglei Xu,Hao Li,Yingzhou Hu,Shihao Wu,Liping Wu,Xiaoguang Lei,Longbao Lv,Yi Lu,Jing Wu, Juanjuan Li, Bingyin Shi,Jiali Li,
ISCIENCEno. 4 (2024): 109436-109436
Xiaosong Liu, Bozidar Novak, Christian Namendorf, Barbara Steigenberger,Yaoyang Zhang,Christoph W. Turck
Science Signalingno. 834 (2024): eadj6603-eadj6603
Sebastian A Giusti, Natalia S Pino, Camila Pannunzio, Mora B Ogando, Natalia G Armando,Lillian Garrett,Annemarie Zimprich,Lore Becker, Maria L Gimeno,Jeronimo Lukin, Florencia L Merino, M Belen Pardi,
Science advancesno. 21 (2024): eadj8769-eadj8769
Journal of psychiatric research (2024): 221-228
Database : the journal of biological databases and curation (2023): 1-3
Hao Li, Leyi Mei, Xiupeng Nie, Liping Wu,Xiaofeng Ren,Longbao Lv, Jitong Yang, Haonan Cao,Jing Wu, Yuhua Zhang,Yingzhou Hu,Wenchao Wang,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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