基本信息
浏览量:44
职业迁徙
个人简介
My clinical training as a pediatric hematology oncology fellow at Memorial Sloan Kettering Cancer Center highlighted the desperate need for novel therapeutic options for a subtype of aggressive pediatric leukemia, Acute Myeloid Leukemia (AML). Despite our best standard of care for AML, long term survival rates range from 50-60% with an unacceptably high relapse rate of 40%. The urgent need for novel treatments inspired me to pursue a research project in adoptive immunotherapy, genetically modifying Tcells to express artificial T cell receptors, termed chimeric antigen receptors (CARs), that target AML specific antigens. In parallel to my clinical training, I constructed an AML specific CAR and demonstrated its ability to redirect T cell function mediating eradication of AML cells. As the field of CAR therapy rapidly advances, novel methods to optimize this therapeutic modality are imperative. To this end, supported by research demonstrating superior antitumor function of naïve derived effector T cells compared to central memory derived effector T cells, I am investigating whether preferential modification of naïve T cells to express CARs will generate a T cell subpopulation with increased efficacy. Consolidating my clinical and research experiences within highly academic institutes allows me to synthesize my pursuit of scientific rigor and commitment to the field of oncology, with a mission to achieve productive research and translatable results.
研究兴趣
论文共 64 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
TRANSPLANTATION AND CELLULAR THERAPYno. 2 (2024): 155-170
Transplantation and Cellular Therapyno. 1 (2024): 75.e1-75.e11
Alexandra Dreyzin, Anne Marijn Kramer,Bonnie Yates,Hao-Wei Wang,Bita Sahaf,Constance Yuan,Zachary Ehlinger,Sunita Patil, Kathryn Martin,Lori S Muffly,Haneen Shalabi,Kara L Davis,
Transplantation and Cellular Therapyno. 2 (2024): S182-S183
Liora M. Schultz,Nikeshan Jeyakumar, Anne Marijn Kramer,Bita Sahaf, Hrishi Srinagesh,Parveen Shiraz, Neha Agarwal,Mark Hamilton,Courtney Erickson,Ashley Jacobs,Jennifer Moon,Christina Baggott,
Leukemiapp.1-6, (2024)
Hannah Lust,Gregory Roloff,Liora Michal Schultz,Lori S Muffly, Jessica Krugman,Ibrahim Aldoss, Soyang Kwon,Michal Kubiak,Catherine J. Lee,Ryan D. Cassaday,Bijal D. Shah,Christina Baggott,
Transplantation and Cellular Therapyno. 2 (2024): S39-S40
Kevin O. McNerney,Amy Moskop,Lena E. Winestone, Julie Talano, Deborah Schiff,Michael R. Verneris,Theodore W Laetsch,Liora Michal Schultz
Transplantation and Cellular Therapyno. 2 (2023): S205-S206
引用0浏览0引用
0
0
Transplantation and cellular therapyno. 2 (2023): 155-170
Kevin O. McNerney, Stephanie Si Lim, Alexandra Miller,Ernest Amankwah,Alexandra Dreyzin,Anant Vatsayan,Michelle Hermiston,Christina Baggott,Snehit Prabhu,Holly L Pacenta,Christine L Phillips,Vanessa A Fabrizio,
Transplantation and Cellular Therapyno. 2 (2023): S202-S203
TRANSPLANTATION AND CELLULAR THERAPYno. 10 (2023): 592-593
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn