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Dr. Farrer’s research has lead to more than 450 publications on genetic risk factors for several familial neurodegenerative and other chronic diseases. In collaboration with other laboratories worldwide, his group has localized genes causing a variety of rare and common disorders, most notably Alzheimer disease (AD), substance use disorders (SUDs), age-related macular degeneration (AMD), Wilson disease, Machado-Joseph disease, Waardenburg syndrome, hypertension, sensorineural deafness, and osteoarthritis. His group identified a functional genetic variant in the complement factor H gene which accounts for more than 30% of the attributable risk for AMD, the leading cause of progressive vision loss and blindness in the elderly. In collaboration with other researchers, Dr. Farrer is conducting genome wide association studies (GWAS) and whole genome/exome sequencing studies for several disorders including AD, SUDs (cocaine, opiates, nicotine, alcohol and cannabis), and AMD. Dr. Farrer’s team is also developing methods for locating genes that influence the natural history of complex diseases and pharmacogenetic response.
研究兴趣
论文共 968 篇作者统计合作学者相似作者
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Nathan Sahelijo,Priya Rajagopalan, Lu Qian, Rufuto Rahman, Dhawal Priyadarshi, Daniel Goldstein, Sophia I Thomopoulos,David A Bennett,Lindsay A Farrer,Thor D Stein, AIAD Consortium,Li Shen,
medRxiv : the preprint server for health sciences (2024)
Habbiburr Rehman,Ting Fang Alvin Ang,Qiushan Tao, Arielle Lauren Espenilla,Rhoda Au,Lindsay A. Farrer,Xiaoling Zhang,Wei Qiao Qiu
JOURNAL OF ALZHEIMERS DISEASEno. 2 (2024): 621-633
NATURE GENETICSno. 5 (2024): 1-17
Exploration of medicineno. 2 (2024): 193-214
Julie Le Borgne,Lissette Gomez,Sami Heikkinen,Najaf Amin,Shahzad Ahmad,Seung Hoan Choi,Joshua Bis,Benjamin Grenier-Boley, Omar Garcia Rodriguez,Luca Kleineidam,Juan Young, Kumar Parijat Tripathi,
medrxiv(2024)
John S. Malamon,John J. Farrell,Li Charlie Xia,Beth A. Dombroski,Rueben G. Das,Jessica Way,Amanda B. Kuzma,Otto Valladares,Yuk Yee Leung, Allison J. Scanlon,Irving Antonio Barrera Lopez, Jack Brehony,
LIFE SCIENCE ALLIANCEno. 5 (2024)
Annals of neurologyno. 4 (2024): 625-634
Journal of Alzheimer's Disease Reportsno. 1 (2024): 575-587
Nicholas R Ray,Brian W Kunkle,Kara Hamilton-Nelson,Jiji T Kurup,Farid Rajabli, Min Qiao, Badri N Vardarajan,Mehmet I Cosacak,Caghan Kizil,Melissa Jean-Francois,Michael Cuccaro,Dolly Reyes-Dumeyer,
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