基本信息
浏览量:6
职业迁徙
个人简介
Dr. Samuelson’s research program examines the development and function of epithelial cells in stomach and intestine. We are interested in how basic developmental pathways, growth factors and immune modulators function to regulate epithelial cell proliferation and differentiation in normal physiology and disease. Our approach is to use genetically engineered mouse models and organ culture systems to interrogate pathways regulating epithelial cell homeostasis. Recent studies have focused on the importance of Notch signaling for regulating stem and progenitor cells. In the intestine, we have determined that Notch plays a fundamental role in cell lineage choice between absorptive enterocytes and secretory cell types (goblet, endocrine, Paneth). These studies identified Atoh1 and Neurogenin3 as key transcriptional effectors regulating secretory cell differentiation. More recent findings demonstrate a distinct function for Notch signaling to maintain the intestinal stem cell. We have also shown that Notch regulates cellular proliferation and cell fate determination in the stomach, thus suggesting that this signaling pathway plays a fundamental role for epithelial cell renewal in the gastrointestinal tract.
研究兴趣
论文共 126 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Wesley Huang,Nupur K Das, Megan D Radyk,Theresa Keeley,Miguel Quiros,Chesta Jain,Marwa O El-Derany, Thaarini Swaminathan, Sofia Dziechciarz,Joel K Greenson,Asma Nusrat,Linda C Samuelson,
The Journal of nutrition (2024)
American Journal of Physiology-gastrointestinal and Liver Physiologyno. 2 (2023): G158-G173
引用0浏览0引用
0
0
American journal of physiology. Gastrointestinal and liver physiology (2023)
引用0浏览0WOS引用
0
0
Nobukatsu Horita,Theresa M Keeley,Elise S Hibdon, Elizabeth Delgado,Daniel Lafkas,Christian W Siebel,Linda C Samuelson
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn