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In comparative genomic studies, the number of protein-coding genes clearly fails to correlate with the developmental and pathological complexity in mammals. Our overall research interest is to understand the unique biological functions and molecular regulation of various non-coding RNAs in development and disease. My postdoctoral work has identified some of the first miRNAs in key oncogene and tumor suppressor pathways. Studies from my own lab has extended beyond mere identification of functionally important miRNAs; we aim to understand the distinct biological functions and molecular regulation conferred by miRNAs and other non-coding elements in development and disease using an interdisciplinary approach combining mouse genetics, genomics, Xenopus genetics, cell biology, and molecular biology. Our studies have provided important insights on the fundamental molecular mechanisms that govern the unique functional complexity of the non-coding genome.
In comparative genomic studies, the number of protein-coding genes clearly fails to correlate with the developmental and pathological complexity in mammals. Our overall research interest is to understand the unique biological functions and molecular regulation of various non-coding RNAs in development and disease. My postdoctoral work has identified some of the first miRNAs in key oncogene and tumor suppressor pathways. Studies from my own lab has extended beyond mere identification of functionally important miRNAs; we aim to understand the distinct biological functions and molecular regulation conferred by miRNAs and other non-coding elements in development and disease using an interdisciplinary approach combining mouse genetics, genomics, Xenopus genetics, cell biology, and molecular biology. Our studies have provided important insights on the fundamental molecular mechanisms that govern the unique functional complexity of the non-coding genome.
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Andrew J Modzelewski,Wanqing Shao,Jingqi Chen,Angus Lee, Xin Qi,Mackenzie Noon, Kristy Tjokro, Gabriele Sales,Anne Biton, Aparna Anand,Terence P Speed,Zhenyu Xuan,
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