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个人简介
I focus on precision medicine approaches to the treatment of lung injury due to inflammation and infection. I use non-invasive diagnostic tools to classify patients into subphenotypes and target the subphenotypes with specific treatments. I currently take the following approaches:
- Pre-clinical models: using cellular and animal models, I try to replicate the biological heterogeneity observed in ICU patients with ARDS to further deepen our understanding of the underlying mechanisms. These models have a focus on injurious innate host responses and endothelial dysfunction.
- Observational studies: broad and inclusive observational studies are well-suited to evaluate the biological and clinical heterogeneity of patients with acute respiratory failure. I'm interested in validation of rapid bedside tests for subphenotype identification and comparison between systemic and alveolar host responses within the subphenotypes.
- Intervention studies: My team is currently undertaking one of the first phase 3 randomized controlled trials using a precision medicine approach. In the PEGASUS trial we use lung ultrasound to assess ARDS subphenotype and provide personalised interventions based on these findings. This is compared to a standard ventilation strategy. Furthermore, I work with an international team of collaborators on establishing the first platform adaptive trial network for precision medicine interventions in ARDS.
研究兴趣
论文共 340 篇作者统计合作学者相似作者
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Roberto Tonelli,Marry R. Smit,Ivana Castaniere,Giovanni Della Casa,Dario Andrisani,Filippo Gozzi,Giulia Bruzzi,Stefania Cerri,Anna Valeria Samarelli, Giulia Raineri, Paolo Spagnolo,Lorenzo Ball,
crossref(2024)
Anthony C Gordon,Narges Alipanah-Lechner,Lieuwe D Bos,Jose Dianti,Janet V Diaz,Simon Finfer,Tomoko Fujii, Evangelos J Giamarellos-Bourboulis,Ewan C Goligher,Michelle Ng Gong,Eleni Karakike,Vincent X Liu,
American journal of respiratory and critical care medicineno. 2 (2024): 155-166
Critical Careno. 1 (2024): 1-15
Trialsno. 1 (2024): 308-308
DIAGNOSTICSno. 4 (2024): 421
Leonoor S. Boers, Frank van Someren Gréve,Jarne M. van Hattem,Justin de Brabander, Tom Zwaan,Hugo van Willigen,Marion Cornelissen,Menno de Jong,Tom van der Poll,JanWillem Duitman, Janke Schinkel,Lieuwe D. J. Bos
Intensive Care Medicinepp.1-14, (2024)
Critical Careno. 1 (2024): 1-14
IJC Heart & Vasculature (2024): 101424-101424
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINEno. 5 (2024): 491-496
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