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During adulthood, a number of organs such as liver, gut, skin and blood rely on continuous stem cell activity for tissue homeostasis and repair. In the adult brain, stem cell activity is limited to a few select niches including the dentate gyrus (DG) of the hippocampal formation. Here, neural stem cells generate functional neurons throughout life in a process termed adult hippocampal neurogenesis. Adult hippocampal neurogenesis is essential for hippocampal information processing and is associated with a number of neuropsychiatric disorders, such as cognitive aging and depression.
Work in our laboratory aims to identify the molecular and cell biological mechanisms controlling adult neurogenesis and neurogenesis-dependent plasticity. Current projects focus on understanding the role of metabolism and cellular homeostasis in stem cell maintenance and on the identification of molecular pathways controlling the maturation and functional integration of adult-generated hippocampal neurons. We are tackling these questions using an integrated in vivo and in vitro approach utilizing a combination of techniques in molecular and cell biology, biochemistry, epigenetics, imaging, and mouse genetics.
In a second line of research our laboratory models the impact of neuropsychiatric disease genes on neurodevelopment using human pluripotent stem cells and CRISPR/Cas9 mediated genome-editing. Here, we focus on elucidating the function of transcription factors associated with intellectual disability, autism and schizophrenia on cortical neurogenesis.
During adulthood, a number of organs such as liver, gut, skin and blood rely on continuous stem cell activity for tissue homeostasis and repair. In the adult brain, stem cell activity is limited to a few select niches including the dentate gyrus (DG) of the hippocampal formation. Here, neural stem cells generate functional neurons throughout life in a process termed adult hippocampal neurogenesis. Adult hippocampal neurogenesis is essential for hippocampal information processing and is associated with a number of neuropsychiatric disorders, such as cognitive aging and depression.
Work in our laboratory aims to identify the molecular and cell biological mechanisms controlling adult neurogenesis and neurogenesis-dependent plasticity. Current projects focus on understanding the role of metabolism and cellular homeostasis in stem cell maintenance and on the identification of molecular pathways controlling the maturation and functional integration of adult-generated hippocampal neurons. We are tackling these questions using an integrated in vivo and in vitro approach utilizing a combination of techniques in molecular and cell biology, biochemistry, epigenetics, imaging, and mouse genetics.
In a second line of research our laboratory models the impact of neuropsychiatric disease genes on neurodevelopment using human pluripotent stem cells and CRISPR/Cas9 mediated genome-editing. Here, we focus on elucidating the function of transcription factors associated with intellectual disability, autism and schizophrenia on cortical neurogenesis.
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bioRxiv the preprint server for biology (2024)
Disease models & mechanismsno. 6 (2023)
Disease Models & Mechanisms (2022)
Development (Cambridge, England)no. 14 (2021)
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