Research Interests
Our research is driven by our interests in understanding how inter- and intracellular signal transduction are implicated in human physiology and diseases. We apply integrative approaches that combine proteomics and systems biology tools to dissect the wiring of signaling networks. Our current focus is to elucidate the mechanisms by which cancer cells and the tumor microenvironment communicate with each other. The reciprocal interactions between cancer cells and the stromal tissues are recognized as a hallmark of cancer that plays a prime role in tumor initiation, growth, angiogenesis, invasion, metastasis, as well as drug resistance. Over the next few years, my team will engage in the following areas of research:

Wnt/planar cell polarity (PCP) signaling in cancer metastasis.
Biology of extracellular vesicles.
Non-conventional roles of immunoglobulins.
Integrative approaches to discover novel cancer targets and therapeutics.