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Current research in the Liang Tong's lab focuses on enzymes involved in fatty acid metabolism, including acetyl-CoA carboxylase, carnitine acyltransferase, AMP-activated protein kinase, and others. These enzymes are important targets for drug discovery against obesity, diabetes and other human diseases. The goal of his research is to produce structural information on these enzymes and to understand their functions at the molecular level. The structural information will also lay the foundation for drug discovery against these targets. Another area of his research is on proteins involved in pre-mRNA 3'-end processing. Most eukaryotic mRNA precursors must undergo cleavage and polyadenylation in their 3'-ends before they can function as mRNAs. This processing machinery contains more than 16 protein factors, which form several sub-complexes (CPSF, CSTF). The goal of his research is to understand the molecular basis of this important event.
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Lindsey C Florek, Xi Lin, Yu-Cheng Lin,Min-Han Lin,Arijit Chakraborty,Alexa Price-Whelan,Liang Tong,Laurence Rahme,Lars E P Dietrich
bioRxiv : the preprint server for biology (2024)
Ji Huang, Xiangyang Liu,Yadong Sun, Zhuang Li,Min-Han Lin,Keith Hamilton,Corey R Mandel,Felix Sandmeir,Elena Conti,Paul H Oyala,Liang Tong
The Journal of biological chemistryno. 4 (2023): 103047-103047
Jian Zhang, Jindou Xie,Ji Huang, Xiangyang Liu, Ruihong Xu,Jonas Tholen,Wojciech P Galej,Liang Tong,James L Manley,Zhaoqi Liu
Genes & developmentno. 21-24 (2023): 968-983
Kechun Wen, Wenting Dai,Xin Meng,Qiao Lin,Jia Wei,Liang Tong,Steven K Taylor,Sergei A Rudchenko,Milan N Stojanovic, Gary Kalantarov,Ilya Trakht
Biosensors & bioelectronics (2023): 115842-115842
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 8 (2023)
Cell chemical biologyno. 1 (2023): 139-149.e14
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