基本信息
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Career Trajectory
Bio
The long-term research goals in Dr. Li’s laboratory are to understand, in mechanistic detail, how RNA viruses enter, replicate, and express genetic information in order to understand viral pathogenesis, and to facilitate the rational design and development of new vaccines and anti-viral drugs. Currently, we are studying RNA viruses that causes respiratory infection including human respiratory syncytial virus (RSV), human metapneumovirus (hMPV), and SARS-CoV-2; and RNA viruses that cause enteric infection including porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and human norovirus.
The Li lab is one of only a few laboratories studying RNA processing and RNA modifications in viruses. During 2004-2008, he characterized mRNA capping enzyme and mRNA cap methyltransferases in non-segmented negative-sense RNA viruses. During 2008-2016, he characterized the roles of mRNA cap methylation in viral replication, pathogenesis, innate and adaptive immunity. Since 2016, the Li laboratory has been focused on characterization of viral and host internal RNA methylation and understand their roles in viral replication, gene expression, and pathogenesis.
The Li lab is one of only a few laboratories studying RNA processing and RNA modifications in viruses. During 2004-2008, he characterized mRNA capping enzyme and mRNA cap methyltransferases in non-segmented negative-sense RNA viruses. During 2008-2016, he characterized the roles of mRNA cap methylation in viral replication, pathogenesis, innate and adaptive immunity. Since 2016, the Li laboratory has been focused on characterization of viral and host internal RNA methylation and understand their roles in viral replication, gene expression, and pathogenesis.
Research Interests
Papers共 88 篇Author StatisticsCo-AuthorSimilar Experts
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Tong Wu,Anthony Youzhi Cheng,Yuexiu Zhang,Jiayu Xu,Jinjun Wu,Li Wen, Xiao Li,Bei Liu,Xiaoyang Dou,Pingluan Wang,Linda Zhang,Jingyi Fei,
Nature Biotechnologypp.1-12, (2024)
Yuexiu Zhang,Michelle Chamblee,Jiayu Xu,Panke Qu,Mohamed M Shamseldin, Sung J Yoo, Jack Misny,Ilada Thongpan,Mahesh Kc,Jesse M Hall, Yash A Gupta,John P Evans,
Nature communicationsno. 1 (2024): 5589-5589
Pei Li, Yajie Liu,Julia Faraone, Cheng Chih Hsu,Michelle Chamblee,Yi-Min Zheng,Claire Carlin,Joseph S. Bednash, Jeffrey C. Horowitz,Rama K. Mallampalli,Linda J. Saif,Eugene M. Oltz,
Pei Li, Julia N. Faraone, Cheng Chih Hsu, Michelle Chamblee,Yi-Min Zheng,Claire Carlin,Joseph S. Bednash, Jeffrey C. Horowitz,Rama K. Mallampalli,Linda J. Saif,Eugene M. Oltz,Daniel Jones,
Cell Reportsno. 8 (2024): 114520-114520
JOURNAL OF GENERAL VIROLOGYno. 8 (2023): 1-55
Journal of medical virologyno. 4 (2023): e28687-e28687
Jiayu Xu,Yuexiu Zhang,Panke Qu,Mohamed M Shamseldin, Sung J Yoo, Jack Misny,Ilada Thongpan,Mahesh Kc,Jesse M Hall,John P Evans,Mostafa Eltobgy,Mijia Lu,
Proceedings of the National Academy of Sciences of the United States of Americano. 41 (2023): e2220403120-e2220403120
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 33 (2022): e2201616119-e2201616119
Proceedings of the National Academy of Sciences of the United States of Americano. 42 (2022): e2123338119-e2123338119
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