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Cell-based gene therapies offer unprecedented promise for medicine. One day, it may be possible to cure degenerative diseases that consist of the loss of one or several specialized cell functions, as well as to decelerate the deterioration our bodies experience during aging. However, several hurdles must be surpassed in order to establish cell transplantation therapies, a major one being rejection by the recipient's immune system. This challenge is particularly prominent for autoimmune disorders, such as type 1 diabetes and multiple sclerosis, where the immune system mediates the destruction of self-tissues. My Ph.D. thesis work, carried out in the laboratories of Jack Strominger and Chad Cowan (Department of Stem Cell and Regenerative Biology) at Harvard University, focused on understanding immune tolerance using pregnancy as a model, as well as developing new tools to interrogate our immune system at the genetic level. As a postdoctoral scholar in the laboratories of Qizhi Tang (Department of Surgery) and Jeff Bluestone (Diabetes Center) at the University of California San Francisco, I designed regulatory T cell therapies for type 1 diabetes and organ transplant rejection. Currently, I am an Assistant Professor of Microbiology and Immunology and, by courtesy, of Regenerative Medicine and Cell Biology at the Medical University of South Carolina and the Hollings Cancer Center. I envision that we will be able to use our capacity to engineer the human genome with high precision and efficiency to manipulate our immune system, enabling us to treat several devastating illnesses now labeled as incurable. I am highly committed to make that vision become a reality.
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论文共 32 篇作者统计合作学者相似作者
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Leonardo M. Ferreira, Russell W. Cochrane, Rob A. Robino, Bryan Granger, Eva Allen, Vishnu Gudivada, Aguirre A. de Cubas,Stefano Berto
Cancer Researchno. 7_Supplement (2024)
Russell W Cochrane, Rob A Robino, Bryan Granger, Eva Allen,Silvia Vaena,Martin J Romeo, Aguirre A de Cubas, Stefano Berto,Leonardo M R Ferreira
bioRxiv : the preprint server for biology (2024)
Methods in molecular biology (Clifton, N.J.) (2024): 243-265
Regenerative medicineno. 4 (2023): 297-299
32nd Annual Meeting North American Skull Base SocietyJournal of Neurological Surgery Part B: Skull Base (2023)
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Leonardo Ferreira,Yannick D. Muller, Anupurna M. Kaul, Hashim Shaikh, Ryan Guerrero-Moreno, Lilian E. Yao,Daniel B. Goodman,Jeffrey A. Bluestone,Qizhi Tang
Leonardo Ferreira,Giovanni A. Carosso,Natalia Montellano Duran,Soad Bohorquez-Massud,Gustavo Vaca-Diez,Laura Ines Rivera-Betancourt,Yara Rodriguez, Dalila G. Ordonez, Diana K. Alatriste-Gonzalez,Aldo Fabian Vacaflores, Lilian Gonzalez Auza,Christian Schuetz,
JOURNAL OF IMMUNOLOGYno. 1 (2020)
bioRxivpp.1-26, (2020)
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