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Leo H Bonati
Hospital de Egas Moniz
Centro Hospitalar Lisboa Ocidental;Stroke Centre (, Lausanne University Hospital;School of Health Sciences, University of Thessaly;Boston Medical Center, Boston University School of Medicine;Comprehensive Stroke Centre, Charles University Faculty of Medicine and University Hospital;2nd Department of Neurology (A.C., M.A.K., M.N.),, Institute of Psychiatry and Neurology;Neurology Department (J.D., R.L.),, Leuven University Hospital;Hospitals and Affiliated Stroke Network (O.Y.M.),, Alexandria University;Department of Neurology, University Hospital of Zurich;Stroke Center (C.W.C., G.B.),, Neurocenter of Southern Switzerland;Bern University Hospital, University of Bern;Stroke Centre (E.C.),, Geneva University Hospital;Department of Neuroradiology, Geneva University Hospital;University Hospital Basel, University of Basel;Stroke Centre (M.B.),, Kantonsspital Lucerne;Stroke Centre (N.P., S.W.),, Hirslanden Hospital;Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental;Department of Neurology, Centro Hospitalar Universitário de Coimbra;Department of Neuroradiology (E.M.),, Centro Hospitalar Universitário de Coimbra;Hospital de São José, Centro Hospitalar Universitário Lisboa Central;Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte;Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte;Department of Neurology (P.C., E.A.),, Centro Hospitalar Universitário São João;Department of Neuroradiology (L.A.),, Centro Hospitalar Universitário São João;Departments of Neurology (J.N.A., J.F.-P.), and Neuroradiology (T.M.),, Hospital de Braga;Department of Neurology (L.P., M.R.),, Hospital Garcia de Orta;Department of Neuroradiology (A.P.A., M.R.),, Centro Hospitalar de Vila Nova de Gaia/Espinho;Department of Neurology (M.R.),, Centro Hospitalar de Vila Nova de Gaia/Espinho;Department of Neurology (A.P.-F, L.R.),, Unidade Local de Saúde de Matosinhos;Department of Neurology (R.V., S.M.),, Centro Hospitalar Universitário do Porto;Stroke Unit (M.C., C.Z.),, Azienda Ospedaliera Universitaria Integrata;Department of Neurology and Stroke Centre, Maggiore Hospital;Department of Neurology (M.S., S.L.G.),, ASST Papa Giovanni XXIII;Department of Clinical and Experimental Sciences (A.P.),, University of Brescia;Department of Neurology and Stroke Unit (D.S.),, Azienda Socio Sanitaria Territoriale;Stroke Unit, Azienda Unità Sanitaria-IRCCS di Reggio Emilia;Neuroradiology Unit (R.P.),, Azienda Unità Sanitaria-IRCCS di Reggio Emilia;San Gerardo Hospital, University of Milano Bicocca;Stroke Unit (G.S.),, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico;Department of Neurology (G.F.),, Policlinico Universitario Agostino Gemelli;Emergency Neurology and Stroke Unit (S.M.),, IRCCS Humanitas Clinical and Research Center;Department of Neurology (C.S., S.E.),, Hôpital Fondation Ade Rothschild;Department of Interventional Neuroradiology (M.P., B.M.),, Hôpital Fondation Ade Rothschild;Department of Interventional Neuroradiology (G.C., F.V.),, Centre Hospitalier Régional Universitaire;Stroke Unit, Centre Hospitalier Universitaire;Department of Interventional and Diagnostic Neuroradiology (J.-S.L., I.S.),, Bordeaux University Hospital;Department of Diagnostic and Interventional Neuroradiology (F.F, G.B., N.-O.G.),, University Medical Center-Hamburg-Eppendorf;University Hospital Frankfurt, Goethe University;Berlin Institute of Health, Charité-Universitätsmedizin Berlin;Department of Neuroradiology (E.S.),, Charité-Universitätsmedizin Berlin;Department of Neurology (, St. John's Hospital;Departments of Neurology, Medical University of Innsbruck;Department of Neurology (J.S., Amsterdam University Medical Centers;Medical Centre, Leiden University;Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel;Department of Neurology (M.P.R, A.G.),, Europe Hospitals;Department of Neurology, Centre Hospitalier Universitaire de Charleroi;Instituto de Investigación Hospital 12 de Octubre (i+12), Hospital Universitario de Octubre;Ramon y Cajal Institute for Health Research (IRYCIS),, Hospital Universitario Ramón y Cajal;La Paz University Hospital, Universidad Autónoma de Madrid;Department of Neurology (S.P.-S., J.M.),, Hospital Universitario Virgen Macarena;Stroke Centre (F.D-.O.),, Hospital General Universitario Gregorio Marañón;Stroke Unit (B.F.-P., J.M.-N.),, Germans Trias Hospital;Comprehensive Stroke Centre, Hospital Clinic from Barcelona;Department of Neurology, Complejo Hospitalario Universitario de Albacete;Department of Neurology, and Interventional Neuroradiology Unit, Hospital Universitario Miguel Servet;Department of Neurology, Hospital Universitario Miguel Servet;Stroke and Geriatric Medicine (T.H.),, Aintree University Hospital;University College London, University College London;Queen Square Institute of Neurology, University College London (D.W.),;Akershus University Hospital, University of Oslo;Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital;at the University of Gothenburg, Sahlgrenska University Hospital;Faculty of Medicine and University Hospital, Charles University;St. Anne´s University Hospital, Masaryk University;Faculty of Medicine, University of Ostrava;Department of Neurology (R.H, S.V.),, České Budějovice Hospital;Department of Neurology (O.S., M.P.),, Jihlava Hospital;Neurocenter (L.J., Z.E., M.J.),, Regional Hospital Liberec;Cerebrovascular Centre (M.K., M.P., P.M.),, Na Homolce Hospital;Department of Neurology (H.P.),, Karviná Miners Hospital Inc.;Cerebrovascular Centre (A.T, P.J, A.O.),, University Hospital in Motol;Cerebrovascular Centre (M.S., R.H, P.M., L.T.),, Central Military Hospital;Cerebrovascular Centre (J.F., M.S.),, General University Hospital;1th Department of Neurology (H.S.-J, A.B.), Institute of Psychiatry and Neurology, Warsaw, Poland;University Hospital, Jagiellonian University;Medical College, Rzeszow University;Department of Neurology and Stroke (M.B, St. John Paul II Western Hospital;Department of Neurology (, Central Clinical Hospital of the Ministry of the Interior and Administration;Departments of Neurology (M.N.-K., K.O., P.U.), and Radiology (M.G.),, Wroclaw Medical University;Department of Neurosurgery and Neurology (M.S.),, Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum;Stroke Intervention Centre (I.R., Jan Biziel University Hospital;Institute of Medical Sciences, University of Opole;Clinic of Neurology (, Military Institute of Medicine;Department of Neurology (J.Z.),, University of Warmia and Mazury;Department of Radiology (C.W.),, Provincial Specialist Hospital;University Emergency Hospital Bucharest, University of Medicine and Pharmacy "Carol Davila",;Department of Radiology, University Emergency Hospital Bucharest;Elias University Emergency Hospital, University of Medicine and Pharmacy "Carol Davila",;Department of Neurology (A.O.),, Eskisehir Osmangazi University;Affiliated Saudi German Hospital, Ain Shams University;Neuropsychiatry Department (H.A.),, Tanta University;Department of Neurology (J.A.-H.),, Ibn Sina Hospital;Department of Neurology (I.I.I.),, Jaber Al-Ahmad Hospital;School of Medicine, Zanjan University of Medical Sciences;Neurology Department, Hillel Yaffe Medical Center;Department of Neurosurgery (P.J., Thomas Jefferson University Hospital;Departments of Radiology (G.A.M., P.G.N.),, Grady Memorial Hospital;Department of Neurology (A.C.),, Henry Ford Hospital;Comprehensive Stroke Centre and Department of Neurosciences (, Michigan State University;Department of Neurology (K.N., S.O.),, University of Arkansas for Medical Sciences;Department of Neurology (M.K.),, Upstate University Hospital;Medical Centre, University of Kansas;Endovascular Neurological Surgery and Neurology (P.K., I.B, M.O., M.B.),, The State University of New Jersey;Detroit Medical Center, Wayne State University;Stroke Clinic (V.C.-N, A.A.),, Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez;Department of Neurology (P.A.),, Fundación Valle del Lili;Centro de Investigaciones Clínicas (N.L., A.A.),, Fundación Valle del Lili;Department of Neurology (M.A.V.),, Hospital Nacional Edgardo Rebagliati Martins;Hospital General San Juan de Dios (J.D.B.G.),;Department of Neurology (R.C., R.T.M.),, Hospital Nossa Senhora da Conceição Hospital;Stroke Unit, Ramos Mejía Hospital (S.D.S.),;St. Luke's Medical Center (P.M.Y.), Global City, Philippines;Department of Neurology (S.N., A.G.),, Grant Medical College and Sir JJ Hospital;Department of Neurology (K.-D.S.),, National Health Insurance Service Ilsan Hospital;School of Biomedical Engineering and Imaging Sciences (G.G.),, King's College London;Department of Clinical Therapeutics (G.G.),, National and Kapodistrian University of Athens;University of Thessaly, Lausanne University Hospital
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个人简介
Prof Leo Bonati, MD, is a clinical Neurologist with special expertise in cerebrovascular disease. His current clinical position is Lead Consultant at the Department of Neurology and Head of the Stroke Center at the University Hospital Basel. He is Research Group Leader at the Department of Clinical Research of the University of Basel.
Prof Bonati obtained his MD and Venia Docendi at the University of Basel. He trained as a clinical Neurologist and clinical researcher in Basel. Supported by a Swiss National Science Foundation stipend, he spent a two-year Research Fellowship at the University College London’s Institute of Neurology (Queen Square).
Prof Bonati’s main research area is the primary and secondary prevention of cerebrovascular disease. He has been involved in design, conduct and interpretation of randomised controlled trials (RCTs) in this field for more than 10 years. Prof Bonati led the main analyses of the pivotal International Carotid Stenting Study (ICSS), the largest RCT comparing carotid artery stenting versus carotid endarterectomy in patients with symptomatic carotid stenosis. Prof Bonati is the Coordinator of the Carotid Stenosis Trialists Collaboration (CSTC), a collaboration between all leading international clinical research groups in the field of carotid disease with the aim of performing pooled analyses of RCT data to select the best treatment for individual patients. Prof Bonati leads several ongoing RCTs in the field of carotid disease: he is the Principal Investigator of the Prevention of Cerebral Ischaemia in Stent Treatment for Carotid Artery Stenosis (PRECISE-MRI) study of optimised antiplatelet therapy in carotid artery stenting; Co-Principal Investigator of the 2nd European Carotid Surgery Trial (ECST-2) comparing invasive revascularisation versus best medical therapy in patients with low-to-intermediate risk carotid disease; and Co-Principal Investigator of the 2nd Asymptomatic Carotid Surgery Trial (ACST-2) comparing endarterectomy versus stenting for asymptomatic carotid stenosis. Prof Bonati’s work in the field of carotid disease, which has been published in numerous articles, including several papers in the Lancet and Lancet Neurology, has influenced stroke prevention guidelines worldwide.
Atrial fibrillation, oral anticoagulation, and their effect on cerebrovascular and other neurological outcomes represent another area of Prof Bonati’s research. He co-initiated the Swiss Registry of New Anticoagulants in Stroke Patients (NOACISP), and is a Member of the Steering Committee in the randomised ELAN trial (Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with Non-valvular atrial fibrillation), which investigates the optimal timing of starting anticoagulation after ischemic stroke. Furthermore, Prof. Bonati is a Steering Committee Member of the Swiss Atrial Fibrillation Cohort Study (Swiss-AF), a large national multicentric cohort aiming to improve clinical management and investigating clinical and subclinical brain injury in patients with atrial fibrillation. Prof Bonati’s responsibility in Swiss-AF is to coordinate analyses of neurological outcomes in the network, encompassing neuroimaging, biomarkers of neuronal injury, cerebrovascular events and neuropsychological studies.
A particular area of Prof Bonati’s expertise is the study of silent vascular brain lesions on magnetic resonance imaging (MRI) as surrogate endpoints in clinical trials and observational studies. Silent brain infarcts visible on MRI are known to occur about twice as often as clinically manifest strokes. Implementation of MRI in prospective studies increases the power to detect treatment effects and risk factor associations, which is of particular use in limited sample sizes. Prof Bonati has extensive experience in the use MRI-based outcome assessment in interventional trials on safety and efficacy of revascularisation treatment and antiplatelet therapy in cerebrovascular atherosclerosis.
Finally, Prof Bonati has coordinated the national implementation of the Swiss Stroke Registry, which captures standardised health outcomes in all patients with acute cerebrovascular disease admitted to primary and comprehensive Stroke Centers in Switzerland (>10’000 patients per year). The Swiss Stroke Registry serves as a central platform for quality assurance, health services research, and prospective observational and interventional studies in acute cerebrovascular disease.
Recently initiated research includes the study of recombinant human C1 esterase inhibitor for neuroprotection in acute stroke; the use of web-based tools for improvement of post-stroke care; and the study of healthy ageing in non-diseased individuals.
研究兴趣
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NUTRIENTSno. 2 (2024): 178
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Annaelle Zietz,Josefin E Kaufmann, Karin Wiesner, Sandro Kevin Fischer, Martina Wiegert, Wilma Dj Verhagen-Kamerbeek, Yannik Rottenberger,Anne Schwarz,Nils Peters,Henrik Gensicke,Friedrich Medlin,Jens Carsten Möller,
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