Leo founded and co-directs Sana, a cross-disciplinary organization based at the Institute for Medical Engineering and Science at MIT, whose objective is to leverage information technology to improve health outcomes in low- and middle-income countries. At its core is an open-source mobile tele-health platform that allows for capture, transmission and archiving of complex medical data (e.g. images, videos, physiologic signals such as ECG, EEG and oto-acoustic emission responses), in addition to patient demographic and clinical information. Sana is the inaugural recipient of both the mHealth (Mobile Health) Alliance Award from the United Nations Foundation and the Wireless Innovation Award from the Vodafone Foundation in 2010. The software has since been implemented around the globe including India, Kenya, Lebanon, Haiti, Mongolia, Uganda, Brazil, Ethiopia, Argentina, and South Africa.