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个人简介
The programmes of work in the laboratory are currently aimed at understanding the molecular mechanisms and physiological significance of intracellular signalling networks which involve a family of enzymes called phosphoinositide 3OH-kinases (PI3Ks).
PI3Ks are now accepted to be critical regulators of numerous important and complex cell responses, including cell growth, division, survival and movement.
PI3Ks catalyse the formation of one or more critical phospholipid messenger molecules, which signal information by binding to specific domains in target proteins. Currently the best understood pathway involves the activation of Class I PI3Ks by cell surface receptors.
In recent years, the laboratory has increasingly focused on the role of PI3Ks in the signalling mechanisms which allow receptors on neutrophils (white blood cells) to control various aspects of neutrophil function.
Neutrophils are key players in the front line of our immune system, responsible primarily for the recognition and destruction of bacterial and fungal pathogens. However, they are also involved in the amplification cascades that underlie various inflammatory pathologies, e.g. Acute Respiratory Distress Syndrome (ARDS) and rheumatoid arthritis.
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论文共 221 篇作者统计合作学者相似作者
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Qian Wang,Chenqi Tao, Yihua Wu,Karen E Anderson, Abdul Hannan, Chyuan-sheng Lin,Phillip T Hawkins,Len Stephens, Xin Zhang
biorxiv(2024)
Qian Wang,Chenqi Tao,Yihua Wu, Karen E Anderson, Abdul Hannan, Chyuan-Sheng Lin,Phillip Hawkins,Len Stephens, Xin Zhang
bioRxiv : the preprint server for biology (2024)
biorxiv(2024)
Victoria Chan,Leslie N. Bone,Karen E. Anderson, Kai Zhang,Laura Orofiamma, Yasmin Awadeh,Daniel K. C. Lee,Norman J. Fu, Jonathan T. S. Chow,Leonardo Salmena,Len R. Stephens,Phillip T. Hawkins,
biorxiv(2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Journal of Clinical Oncologyno. 16_suppl (2023): e21585-e21585
Tamara A M Chessa, Piotr Jung, Arqum Anwar,Sabine Suire,Karen E Anderson,David Barneda,Anna Kielkowska, Barzan A Sadiq, Ieng Wai Lai,Sergio Felisbino,Daniel J Turnham, Helen B Pearson,
Pui Ying Chan,Victoria Harle,Victoria Offord,Kim Wong,David Barneda,Phillip Hawkins,Len Stephens, Anjan Venkatesh,Colm J. Ryan, David J. Adams
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023)
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NATUREno. 7963 (2023): 159-168
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