![https://static.aminer.cn/upload/avatar/1823/130/1942/5631eeb545cedb3399f6374b_0.jpeg](https://avatarcdn.aminer.cn/upload/avatar/1823/130/1942/5631eeb545cedb3399f6374b_0.jpeg!160)
Suzanne Leal
Professor
Gertrude H. Sergievsky Center;Center for Statistical Genetics
Baylor College of Medicine;Columbia University in the City of New York;Department of Neurology, Irving Medical Center, Columbia University;The Neurological Institute of New York, Irving Medical Center, Columbia University
Follow
Claim
分享
Follow
Claim
分享
基本信息
views: 6
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
My primary interest lies in understanding the genetic etiology of complex and Mendelian traits, with an emphasis on developing and applying statistical and epidemiological methods to tackle these complex problems. I have worked extensively on method and software development to aid in gene identification and elucidating the genetics of disease etiology. One of my interests is developing methods to analyze rare variants obtained from sequence data, including methods to analyze family data, detect epistasis, and pleiotropy. My publication on the combined multivariate collapsing (CMC) method was the first article to describe a rare-variant aggregate test to detect complex disease associations. I have also developed additional methods to identify associations with rare variants with application to population- and family-based sequence data. Rare-variant aggregate methods were also developed to perform parametric and non-parametric linkage analysis. Additionally, methods were developed to estimate the effect sizes for rare variants; simulate rare variants to compare methods and estimate power and type I error; and estimate sample sizes for complex and Mendelian traits.
Research Interests
Papers共 375 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Brain communicationsno. 3 (2024): fcae142-fcae142
Isabelle Schrauwen, Yasmin Rajendran,Anushree Acharya, Susanna Öhman,Maria Arvio,Ritva Paetau,Auli Siren,Kristiina Avela, Johanna Granvik,Suzanne M Leal,Tuomo Määttä,Hannaleena Kokkonen,
Scientific reportsno. 1 (2024): 11239-11239
Tommi Salokivi,Riitta Parkkola, Yasmin Rajendran,Thashi Bharadwaj,Anushree Acharya,Suzanne M. Leal,Irma Jarvela,Maria Arvio,Isabelle Schrauwen
AMERICAN JOURNAL OF MEDICAL GENETICS PART Ano. 4 (2024): e63478-e63478
Irma Jarvela,Ritva Paetau,Thashi Bharadwaj,Suzanne Leal,Anushree Acharya, Anna-Elina Lehesjoki,Isabelle Schrauwen
EUROPEAN JOURNAL OF HUMAN GENETICS (2024): 527-527
Cited0Views0Bibtex
0
0
European Journal of Human Geneticsno. 12 (2023): 1447-1454
Dong-Chuan Guo,Xueyan Duan, Kathleen Mimnagh,Alana C Cecchi,Isabella C Marin, Yang Yu, Walter V Velasco,Kwanghyuk Lee, Xue Zhu,David R Murdock,Suzanne M Leal,Marsha M Wheeler,
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn