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个人简介
Why do some individuals develop disease? Broadly speaking, genetic risk polymorphisms and environmental exposures act in concert with stochastic factors to influence risk for many diseases. Recent studies are beginning to identify the disease mechanisms impacted by specific genetic risk variants and environmental exposures. In particular, functional genomics-based approaches are revealing that changes in human chromatin state and gene expression are important molecular mechanisms through which genetic and environmental factors influence human disease risk. Understanding disease mechanisms is vitally important for the development of treatments and therapies. In the past two decades, thousands of genetic variants with roles in >1,500 human diseases have been identified. Importantly, genetic association studies do not identify causal SNPs, critical genes, or etiological pathways. There is a pressing need for new approaches that translate the massive results from genetic studies into clear mechanistic understandings of the genetic and environmental contributions to human diseases.
The Kottyan laboratory is part of a multidisciplinary team called the Transcription Factor Genetics working group. A major strength of this arrangement is the mixing of experimental and computational backgrounds among topics, and therefore trainees. The multidisciplinary complementation among the principle investigators and their teams provides the conceptual synergy driving many collaborative projects. Dynamic interactions between people in the wet lab performing functional genomic experiments and the people developing the analytical pipelines enables high quality, robust scientific discovery. I bring unique and independent expertise, leadership, and funding to projects on which we work together.
My lab's goals are to:
• Identify molecular mechanisms to explain how genetic polymorphisms increase risk of immune-associated diseases.
• Develop new ways to treat diseases that target genotype-dependent disease risk pathways.
• Train and empower scientists and clinicians in my laboratory.
研究兴趣
论文共 193 篇作者统计合作学者相似作者
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Gastroenterologyno. 5 (2024): S-14-S-15
medRxiv : the preprint server for health sciences (2024)
Khund Sayeed,Sreeja Parameswaran,Matthew J Beucler,Lee E Edsall,Andrew VonHandorf, Audrey Crowther,Omer Donmez,Matthew Hass, Scott Richards,Carmy Forney, Jay Wright,Merrin Man Long Leong,
bioRxiv : the preprint server for biology (2024)
Dai Dai,Shuangshuang Gu,Xiaxia Han,Huihua Ding, Yang Jiang, Xiaoou Zhang,Chao Yao,Soonmin Hong,Jinsong Zhang,Yiwei Shen,Guojun Hou,Bo Qu,
Science (New York, N.Y.)no. 6681 (2024): 413-421
Kenyatta C. M. F. Viel,Sreeja Parameswaran,Omer A. Donmez,Carmy R. Forney,Matthew R. Hass, Cailing Yin, Sydney H. Jones, Hayley K. Prosser, Arame A. Diouf, Olivia E. Gittens,Lee E. Edsall,Xiaoting Chen,
bioRxiv the preprint server for biology (2024)
Samuel J Virolainen,Latha Satish,Jocelyn M Biagini, Hassan Chaib,Wan Chi Chang,Phillip J Dexheimer, Michael R Dixon,Katelyn Dunn, David Fletcher,Carmy Forney,Marissa Granitto, Matthew S Hestand,
JCI insightno. 9 (2024)
Lindsay Guare, Leigh Ann Humphrey,Margaret Rush, Meredith Pollie,Yuan Luo,Chunhua Weng,Wei-Qi Wei,Leah Kottyan,Gail Jarvik,Noemie Elhadad,Penn Medicine Biobank,Regeneron Genetics Center,
medRxiv : the preprint server for health sciences (2024)
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