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Bio
Larry Dick has been studying the Ubiquitin Proteasome System for over 30 years. He began this work as a postdoctoral fellow with Drs. Clive Slaughter and George DeMartino at UT Southwestern Medical Center. He helped to start the biotech company MyoGenics, where he worked on the team that discovered the widely used proteasome inhibitor research compound, MG-132, and the first-in-class proteasome inhibitor multiple myeloma drug, VELCADE. Subsequently, he led the proteasome inhibitor discovery team at Millennium Pharmaceuticals that produced NINLARO, the first oral proteasome inhibitor approved for relapsed refractory multiple myeloma. Additionally, at Millennium/Takeda, he led the team that discovered adenosine sulfamate analogs as potent inhibitors of ubiquitin-like protein activating enzymes and described their novel mechanism of action. To date those efforts have yielded three first-in-class investigational oncology drugs: pevonedistat (MLN4924), an inhibitor of NEDD8 activating enzyme in a phase 3 clinical trial for acute myeloid leukemia, TAK-243 (MLN7243), an inhibitor of ubiquitin activating enzyme in phase 1 trials, and TAK-981, an inhibitor of SUMO activating enzyme recently started in phase 1. Currently he is an independent drug discovery consultant for several biotechnology companies and an Honorary Fellow in the group of Professor Leann Tilley at the University of Melbourne Bio21 Institute working on antimalarial drug discovery with scientists from Medicines for Malaria Venture in Geneva Switzerland and Takeda Oncology in Cambridge Massachusetts.
Research Interests
Papers共 77 篇Author StatisticsCo-AuthorSimilar Experts
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Stanley C. Xie, Chia-Wei Tai,Craig J. Morton,Liting Ma,Shih-Chung Huang, Sergio Wittlin,Yawei Du,Yongbo Hu,Con Dogovski, Mina Salimimarand,Robert Griffin,Dylan England,
biorxiv(2024)
crossref(2023)
crossref(2023)
crossref(2023)
crossref(2023)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 39 (2021)
Elizabeth C Unan,Hiroya Matsuoka,Hirofumi Hasuda, Soumya Malhotra, Siddhartha Pulukuri, Victor Bacelar,Allison Berger,Nibedita Chattopadhyay,Lawrence Dick,Eiji Oki,Koji Ando,Ajit Bharti
crossref(2021)
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