基本信息
views: 32
Career Trajectory
Bio
Laurence Pearl is a structural biologist who has used X-ray crystallography and other techniques to reveal the size, shape and composition of molecules vital to life. Taking cues from these structures to understand their function, he has worked on the design of potential drugs for diseases including cancer.
His early breakthrough was the discovery that an HIV enzyme could be a target for AIDS therapy. Laurence has since focused on large, complex molecules that play a variety of essential housekeeping roles: repairing damaged DNA; passing on intracellular signals; or acting as ‘molecular chaperones’ in the formation of other protein complexes.
Laurence’s work on the molecular interactions of the chaperone Hsp90 has led to new anti-tumour agents that block this protein from activating cancer-causing proteins. He continues his academic work in parallel with his role in the drug discovery company he founded, and as the Head of the School of Life Sciences at the University of Sussex. In 2013, he shared the Cancer Research UK Translational Cancer Research Prize.
Research Interests
Papers共 237 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Matthew Day,Bilal Tetik, Milena Parlak,Yasser Almeida-Hernández,Markus Räschle,Farnusch Kaschani, Heike Siegert,Anika Marko,Elsa Sanchez-Garcia,Markus Kaiser, Isabel A. Barker,Laurence H. Pearl,
Nature Communicationsno. 1 (2024): 1-20
FEBS letters (2024)
crossref(2023)
crossref(2023)
crossref(2023)
crossref(2023)
Matthew Day,Bilal Tetik, Milena Parlak,Yasser Almeida‐Hernández,Markus Räschle,Farnusch Kaschani, Heike Siegert,Anika Marko,Elsa Sánchez-García,Markus Kaiser, Isabel A. Barker,Laurence H. Pearl,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
crossref(2023)
crossref(2023)
crossref(2023)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn