基本信息
浏览量:32
职业迁徙
个人简介
Our laboratory is interested in the role of drug reduction pathways in the toxicity of arylamine compounds, including both therapeutic drugs and environmental carcinogens. Arylamines become toxic through the formation of hydroxylamine metabolites. We have characterized the enzymatic detoxification of hydroxylamines by a novel xenobiotic reduction pathway, comprised of cytochrome b5 and NADH cytochrome b5 reductase. We are working to identify pharmacogenetic variability in this pathway, and its relationship to drug hypersensitivity to the arylamine antimicrobial sulfamethoxazole. We are also examining the role of variability in the expression of cytochrome b5 and NADH cytochrome b5 reductase, and the development of DNA adducts in tissues exposed to the arylamine carcinogens.
研究兴趣
论文共 85 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Samantha L. Braman,Hannah Peterson, Amy Elbe, Erin Mani, Camille Danielson,Christa Dahman,Julia D. Labadie,Lauren A. Trepanier
VETERINARY AND COMPARATIVE ONCOLOGY (2024)
JOURNAL OF VETERINARY INTERNAL MEDICINE (2024)
Journal of veterinary internal medicine (2023)
Journal of Veterinary Internal Medicineno. 3 (2023): 960-967
引用1浏览0引用
1
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn