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Bio
Our laboratory is interested in the role of drug reduction pathways in the toxicity of arylamine compounds, including both therapeutic drugs and environmental carcinogens. Arylamines become toxic through the formation of hydroxylamine metabolites. We have characterized the enzymatic detoxification of hydroxylamines by a novel xenobiotic reduction pathway, comprised of cytochrome b5 and NADH cytochrome b5 reductase. We are working to identify pharmacogenetic variability in this pathway, and its relationship to drug hypersensitivity to the arylamine antimicrobial sulfamethoxazole. We are also examining the role of variability in the expression of cytochrome b5 and NADH cytochrome b5 reductase, and the development of DNA adducts in tissues exposed to the arylamine carcinogens.
Research Interests
Papers共 98 篇Author StatisticsCo-AuthorSimilar Experts
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Samantha L Braman,Hannah Peterson, Amy Elbe, Erin Mani, Camille Danielson,Christa Dahman,Julia D Labadie,Lauren A Trepanier
Veterinary and comparative oncologyno. 2 (2024): 217-229
Courtney N Patson, Elizabeth J Elsmo,Lauren Trepanier,Michael M Garner,Michael J Murray,Ellen Bronson, Lorelei L Clarke,Sherry K Cox,Robert J Ossiboff,Marley E Iredale,Bryce M Miller, Lindsey Waxman,
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinariansno. 2 (2024): 479-489
Journal of veterinary internal medicineno. 3 (2023): 960-967
Canine Medicine and Geneticsno. 1 (2022): 1-10
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