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Research summary
Our research focuses on a class of proteins with very distinctive architectures, known as tandem-repeat proteins. Our group and others have shown that the simple modular, one-dimensional architecture of tandem-repeat proteins gives them distinctive properties that make it uniquely straightforward to map the energetics of their structures and to rationally redesign their stability, folding and binding function.
This class of proteins is thus an exceptionally sensitive and versatile tool that we are now exploiting to dissect otherwise intractable cellular mechanisms. We are also exploring how to exploit the extraordinary design-ability of these proteins for biomedical and biotechnology applications.
Our research focuses on a class of proteins with very distinctive architectures, known as tandem-repeat proteins. Our group and others have shown that the simple modular, one-dimensional architecture of tandem-repeat proteins gives them distinctive properties that make it uniquely straightforward to map the energetics of their structures and to rationally redesign their stability, folding and binding function.
This class of proteins is thus an exceptionally sensitive and versatile tool that we are now exploiting to dissect otherwise intractable cellular mechanisms. We are also exploring how to exploit the extraordinary design-ability of these proteins for biomedical and biotechnology applications.
Research Interests
Papers共 181 篇Author StatisticsCo-AuthorSimilar Experts
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CURRENT OPINION IN STRUCTURAL BIOLOGY (2024): 102744-102744
crossref(2024)
Veerpal Kaur,Demelza Wright,Samuel Mathew, Matthew Peters,Maria Zacharopoulou,Shang Hua Yang,Laura S Itzhaki,Ivet Bahar,Reuven Gordon
JPhys Photonicsno. 3 (2024): 035023
Tin Long Chris Ng,Mateo P. Hoare, M. Julia Maristany, Ellis J. Wilde,Tomas Sneideris,Jan Huertas, Belinda K. Agbetiameh, Mona Furukawa,Jerelle A. Joseph,Tuomas P.J. Knowles,Rosana Collepardo-Guevara,Laura S. Itzhaki,
biorxiv(2024)
Mateo P Hoare, Daniel Mcilwaine,Tin Long Chris Ng,Luisa Capalbo, Ellis J Wilde,Laura S Itzhaki,Janet R Kumita
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERSno. SUPPL 1 (2023): S44-S44
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PROTEIN SCIENCE (2023)
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Author Statistics
#Papers: 181
#Citation: 5053
H-Index: 36
G-Index: 68
Sociability: 6
Diversity: 3
Activity: 68
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