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个人简介
Laura’s work focuses on how bacteria develop resistance to antibiotics. This is a growing problem, as more strains of bacteria become resistant to the drugs that were primarily developed more than 20 years ago. Her research focuses on how antibiotic resistance arises, and defining and characterising mechanisms of resistance that have a clinical relevance.
She is also exploring the role of antibiotic resistance mechanisms in the ability of the organism to colonise, survive and cause infection in their host. Laura is particularly interested in the systems that allow transport of antibiotics into and out of bacteria. Adaptations to these systems occur in bacteria and cause multiple drug resistance. Although this work has many applications, Laura has made particularly detailed studies of food borne bacteria such as Salmonella and Campylobacter, and the pneumococcus that causes pneumonia.
Current work is in three areas (1) mechanisms of regulation of expression of Gram bacterial efflux pumps and how this impacts upon the ability of the bacterium to infect the host, (2) identifying inhibitors of efflux, and (3) inhibition of transfer of plasmids (mobile genetic elements) between bacteria.
Laura receives support for her research from the MRC and BBSRC and she has a Roche 'Extending the Innovation Network' Award. Since 1985 Laura has successfully supervised 30 PhD projects. Her team currently comprises 4 post-doctoral research fellows, 2 technicians, and 1 postgraduate student.
研究兴趣
论文共 354 篇作者统计合作学者相似作者
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Benjamin Blasco,Soojin Jang,Hiroki Terauchi, Naoki Kobayashi,Shuichi Suzuki,Yuichiro Akao,Atsuko Ochida,Nao Morishita,Terufumi Takagi, Hiroyuki Nagamiya, Yamato Suzuki, Toshiaki Watanabe,
EBioMedicine (2024): 105073-105073
Biljana Kakaraskoska Boceska,Tuba Vilken,Basil Britto Xavier,Tomislav Kostyanev,Qiang Lin,Christine Lammens,Sally Ellis,Seamus O'Brien, Renata Maria Augusto da Costa,Aislinn Cook,Neal Russell,Julia Bielicki,
Nature communicationsno. 1 (2024)
BRITISH JOURNAL OF PHARMACOLOGY (2023): 450-451
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Antimicrobial agents and chemotherapyno. 11 (2023): e0062023-e0062023
Alasdair P. Macgowan, M. L. G. Attwood,Alan R. Noel, R. Barber,Zachary Aron,Timothy J. Opperman,Elizabeth Grimsey,Jack Stone,Vito Ricci,L. J. Piddock
The Journal of antimicrobial chemotherapyno. 12 (2023): 2869-2877
Biljana Kakaraskoska Boceska,Tuba Vilken,Basil Britto Xavier,Christine Lammens,Sally Ellis,Seamus O’Brien, Renata Maria Augusto da Costa,Aislinn Cook,Neal Russell,Julia Bielicki,Eitan Naaman Berezin, Emmanual Roilides,
medRxiv (Cold Spring Harbor Laboratory) (2023)
Microbiology (Reading, England)no. 5 (2023)
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#Papers: 357
#Citation: 31420
H-Index: 82
G-Index: 172
Sociability: 7
Diversity: 3
Activity: 45
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